Endotoxin pp 467-480 | Cite as

Regulatory Mechanism of Expression of LPS Binding Site(S) and Signaling Events by LPS in Macrophages

  • K. S. Akagawa
  • K. Kamoshita
  • T. Tomita
  • T. Yasuda
  • T. Tokunaga
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)


Lipopolysaccharide (LPS) from gram-negative microorganisms is a potent activator of macrophages. LPS induces macrophages to secrete immunoregulatory substances including interleukin 1 (IL 1), tumor necrosis factor (TNF), interferon, colony stimulating factors (CSFs) and, prostaglandins. Furthermore LPS activates tumor cytotoxicity of macrophages by itself or in combination with interferon.


Peritoneal Macrophage Pertussis Toxin Peritoneal Exudate Cell Tumor Necrosis Factor Production Dibutyryl cAMP 


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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • K. S. Akagawa
    • 1
  • K. Kamoshita
    • 1
  • T. Tomita
    • 2
  • T. Yasuda
    • 2
  • T. Tokunaga
    • 1
  1. 1.Department of Cellular ImmunologyNational Institute of HealthShinagawa-ku, Tokyo 141Japan
  2. 2.The Medical InstituteUniversity of TokyoMinato-ku, Tokyo 108Japan

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