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Endotoxin pp 399-402 | Cite as

Comparative Study of Lipopolysaccharide-, Lipid IVa-, and Lipid X-Induced Tumor Necrosis Factor Production in Murine Macrophage-Like Cell Lines

  • T. P. Birkland
  • R. D. Cornwell
  • D. T. Golenbock
  • R. A. Proctor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)

Abstract

Tumor necrosis factor (TNF) was initially described in the sera of Mycobacterium bovis strain BCG infected mice treated with endotoxin (2) and defined by its ability to cause necrosis of tumors in mice. In addition to this potentially beneficial effect, TNF has been shown to be intimately involved in the pathophysiology of bacterial lipopolysaccharide (LPS)-induced shock and lethality in mice (1). In both instances, the primary sources of TNF are macrophages (5).

Keywords

MYcobacterium Bovis Tumor Necrosis Factor Production Tumor Necrosis Factor Activity Induce Tumor Necrosis Factor Production Tumor Necrosis Factor Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Mannel, D. N., Falk, W., Meltzer, M. S., 1981, Inhibition of nonspecific tumoricidal activity by activated macrophages with antiserum against a soluble cytotoxic factor. Infect. Immun. 33: 156.PubMedGoogle Scholar
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    Strain, S. M., Armitage, I. M., Anderson, L., Takayama, K., Quereshi, N., and Raetz, C. R. H., 1985, Location of polar substituents and fatty acyl chains on Lipid A precursors from a 3-deoxy-D-manno-octulosonic acid-deficient mutant of Salmonella typhimurium. J. Biol. Chem. 260: 1608916098.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • T. P. Birkland
    • 1
  • R. D. Cornwell
    • 1
  • D. T. Golenbock
    • 1
  • R. A. Proctor
    • 1
  1. 1.Department of Medical MicrobiologyUniversity of Wisconsin Medical SchoolMadisonUSA

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