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Endotoxin pp 341-344 | Cite as

Mechanisms of Neutralization of Endotoxin by Monoclonal Antibodies to O and R Determinants of Lipopolysaccharide

  • T. Sagawa
  • Y. Hitsumoto
  • M. Kanoh
  • S. Utsumi
  • S. Kimura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)

Abstract

The protective potentials of antibodies to O and R core regions of lipopolysaccharide (LPS) have been amply substantiated (2, 7). However, the efficacy of antibodies to the toxic lipid A moiety itself is still ambiguous, and how antibodies to regions distal from lipid A can neutralize the toxicity remains to be clarified. We have compared the effects of mouse monoclonal antibodies (mAbs) of IgG class to these three regions of LPS on the biological activities as well as micellic structure of LPS, in order to shed light on the mechanism of neutralization of endotoxin by these antibodies.

Keywords

PGE2 Production Sucrose Density Gradient Protective Potential Endotoxin Shock Toxic Lipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • T. Sagawa
    • 1
  • Y. Hitsumoto
    • 2
  • M. Kanoh
    • 2
  • S. Utsumi
    • 2
  • S. Kimura
    • 1
  1. 1.Second Department of SurgeryEhime University, School of MedicineShigenobu-cho OnsengunJapan
  2. 2.Department of MicrobiologyEhime University, School of MedicineShigenobu-cho OnsengunJapan

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