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Endotoxin pp 13-43 | Cite as

Structural Requirements of Lipid a for Endotoxicity and Other Biological Activities—An Overview

  • S. Kotani
  • H. Takada
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)

Abstract

Lipopolysaccharide (LPS), a major constituent of outer membranes of gram-negative bacteria, exhibits a wide variety of bioactivities (Table 1) (61). In 1954 Westphal and Lüderitz proposed that the lipid moiety of LPS is responsible for most of endotoxicities, and designated it as lipid A (Fig 1) (60). However, this extremely important discovery was neither adequately nor unanimously accepted by endotoxin investigators at that time. One of the main reasons for this controversy is that the high hydrophobicity of the lipid A molecule made its manipulation as a test material for bioactivities difficult. Another reason is concerned with inherent microheterogeneity in fine structures even among preparations derived from the same bacterial

Keywords

Chick Embryo Structural Requirement Horseshoe Crab Lethal Toxicity Synthetic Lipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • S. Kotani
    • 1
    • 2
  • H. Takada
    • 1
  1. 1.Department of Microbiology and Oral MicrobiologyOsaka University Dental SchoolSuitaOsaka 565Japan
  2. 2.Osaka College of Medical TechnologyKita-kuOsaka 530Japan

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