Lipoamino Acids which are Similar to Bacterial Endotoxin in Both Structure and Biological Activity Related to Physiological Function
Lipoamino acids are the substances which are present as the constituents of the cell membranes of relatively wide range of bacteria. As shown in Fig 1, the structures possess both hydrophobic lipid moiety and hydrophilic amino acid moiety (Ser or Orn) (3, 4, 5). We have investigated the structures and hemagglutinating activity of some lipoamino acids from Bordetella (3), Flavobacterium (4) and Pseudomonas (5). From these studies, it was resolved that the lipoamino acids possessing the fatty acids of carbon number 16–16 or 17–15 exhibit the higher hemagglutinating activity. Serine-containing lipid was found only in Flavobacterium and was named ‘Flavolipin’ by us (4). Based on these studies, we used this time the two kinds of lipoamino acids of Flavobacterium shown in Fig 1.
KeywordsBacterial Endotoxin Hemagglutinating Activity Mouse Peritoneal Macrophage Produce Tumor Necrosis Factor Hydrophilic Amino Acid
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