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Multiple Roles for Poly(ADP-Ribose) Synthesis in Repair of DNA Damage and Malignant Transformation

  • Carmia Borek
  • James E. Cleaver
Chapter

Abstract

Poly(ADP-ribosyl)ation inhibits the activity of many enzymes associated with DNA metabolism, including polymerases, ligases, topoisomerases and endonucleases, and depletes cells of essential cofactors such as NAD and ATP. In cells exposed to DNA damaging agents, inhibition of poly(ADP-ribosyl)ation accelerates strand break rejoining and stimulates additional DNA breakage by endogenous nucleases. The net single-strand break frequencies can therefore be increased or decreased by inhibitors of poly(ADP-ribose) polymerase such as 3-aminobenzamide, according to the relative importance of the two opposing biochemical effects on DNA breakage in different cell types. Transformation and promotion of cells in vitro can also be inhibited by 3-aminobenzamide during the early times after exposure to the initiating or promoting agents, but the relationship of this to DNA repair is nuclear.

Keywords

Strand Break Patch Size Nicotinamide Adenine Dinucleotide Break Frequency Repair Patch 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Carmia Borek
    • 1
  • James E. Cleaver
    • 2
  1. 1.Radiation Research LaboratoryColumbia University College of Physicians and SurgeonsNew YorkUSA
  2. 2.Laboratory of Radiobiology and Environmental HealthUniversity of CaliforniaSan FranciscoUSA

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