Mechanisms of Hydrogen Peroxide Cytotoxicity in Mammalian and Bacterial Cells

  • Orazio Cantoni
  • Girogio Brandi
  • Peter Cerutti
  • Raymond E. Meyn
  • David Murray


The study of the lethal and mutagenic effects of partially-reduced oxygen species such as hydrogen peroxide and superoxide is important for several reasons. Many chemotherapeutic agents generate activated oxygen species during their metabolism1, and these may have an important role in the toxicity of these drugs. Furthermore, these same species have been proposed to have an important role in tumor promotion2 and in the inflammatory response3. Finally, studies with activated oxygen species can provide insights into the cellular effects of γ-radiation4,5, although there is only partial similarity between these damaging agents. The present paper summarizes recent collaborative studies among our laboratories on the mechanisms of hydrogen peroxide-induced lethality in both mammalian and bacterial cells, and compares these results with those obtained in other laboratories.


Chinese Hamster Ovary Cell Activate Oxygen Species Induce Cell Killing Mutant Chinese Hamster Ovary Cell Distinct Target Site 


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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Orazio Cantoni
    • 1
  • Girogio Brandi
    • 2
  • Peter Cerutti
    • 3
  • Raymond E. Meyn
    • 4
  • David Murray
  1. 1.Istituto di Farmacologia e Farmacognosia and Centro di Farmacologia Oncologia SperimentaleUniversita degli Studi di UrbinoItaly
  2. 2.Istituto di Scienze Tossicologiche, Igienistiche ed AmbientaliUniversita degli Studi di UrbinoItaly
  3. 3.Department of CarcinogenesisSwiss Institute for Experimental Cancer ResearchEpalinges, LausanneSwitzerland
  4. 4.Department of Experimental RadiotherapyM.D. Anderson HospitalHoustonUSA

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