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Antineoplastic Agents Inhibitor of Topoisomerase II

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DNA Damage and Repair

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Abstract

The extreme length of the DNA molecules in the nuclei of eukaryotic cells, as well as the possible attachment of the DNA to a structural matrix or scaffold in the nuclei, constrains the topology of the DNA helices. The topological constraint is that the two strands of a DNA helix are unable to change the number of turns of one strand about the other (the “linking number”, Lk), unless one or both strands are temporarily cut to form a gap through which other parts of the strands can pass. The topoisomerases provide mechanisms for such cutting and passing of strands, without which the DNA helix cannot unwind and replicated chromosomes cannot segregate.

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Authors and Affiliations

  1. Laboratory of Molecular Pharmacology, DCT, NCI BLDG 37, RM 5A19, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Yves Pommier, Donna Kerrigan, Christine Jaxel, Joseph M. Covey, Elliott Ulhenhopp & Michael R. Mattern

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  1. Yves Pommier
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  2. Donna Kerrigan
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  3. Christine Jaxel
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  1. Department of Environment and Health Protection, ENEA, Rome, Italy

    Amleto Castellani

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Pommier, Y., Kerrigan, D., Jaxel, C., Covey, J.M., Ulhenhopp, E., Mattern, M.R. (1989). Antineoplastic Agents Inhibitor of Topoisomerase II. In: Castellani, A. (eds) DNA Damage and Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5016-4_24

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  • DOI: https://doi.org/10.1007/978-1-4757-5016-4_24

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