DNA Strand Bias During O6-Methylguanine Mutagenesis

  • John M. Essigmann


One of the common characteristics of chemical carcinogens and mutagens is their ability to form covalent products with DNA known collectively as adducts. Misreplication or misrepair of DNA adducts can lead to mutations, which in turn can act as the genetic precursors of cancer and other genetic diseases. A problem in contemporary cancer biology has been to discern the mechanisms by which DNA adducts lead to mutations. This problem is complicated by the fact that DNA damaging agents usually form not one, but many DNA lesions. As a result, it is a challenging task to assess the relative contributions of individual DNA adducts to the biological endpoint of mutation.


Replicative Form Covalent Product Phage Population Progeny Phage Mutant Phage 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • John M. Essigmann
    • 1
  1. 1.Department of Applied Biological SciencesMassachusetts Institute of TechnologyCambridgeUSA

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