Neuronal Death and Neurotrophic Factors

  • Marcus Jacobson


The tyranny of theory over the evidence is nowhere more glaringly evident than in the history of the delayed discovery of neuronal death during normal development. The tyranny in this case was imposed by the theory that both ontogeny and phylogeny are progressive, from lower and less organized to higher and more organized nervous systems. Evidence of neuronal death during normal development was reported but was ignored because it was in conflict with the idea of progressive development. Reports of neuronal death were buried in the literature, to be unearthed much later as curious historical relics. Such reports come back to haunt us as they haunted previous generations who could not accept evidence that conflicted with their cherished theories.


Dorsal Root Ganglion Neurotrophic Factor Chick Embryo Dorsal Root Ganglion Neuron Retinal Ganglion Cell 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Marcus Jacobson
    • 1
  1. 1.The University of Utah School of MedicineSalt Lake CityUSA

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