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Neutrophil Degranulation

  • Ira M. Goldstein
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 14)

Abstract

Metchnikoff (1883) is credited with formulating the concept that acute inflammation in virtually all multicellular organisms occurs largely as a consequence of a coordinated series of events whereby phagocytic cells attempt to defend the host against foreign invaders. This concept and Metchnikoff’s remarkable insight are illustrated by the following quotation (Metchnikoff, 1905):

But it is not micro-organisms only which set up this inflammatory reaction accompanied by the emigration and accumulation of leucocytes. The introduction of inert bodies and of aseptic fluids brings about the same result. The phagocytes are, as a matter of fact, endowed with a special susceptibility, which enables them to perceive exceedingly small changes in the chemical or physical composition of the medium that surrounds them.

The leucocytes, having arrived at the spot where the intruders are found, seize them after the manner of the Amoebae and within their bodies subject them to intracellular digestion. This digestion takes place in the vacuoles in which usually is a weakly acid fluid which contains digestive ferments; of these a very considerable number are now recognised.

Keywords

Lysosomal Enzyme Human Neutrophil Polymorphonuclear Leukocyte Chronic Granulomatous Disease Arachidonic Acid Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Ira M. Goldstein
    • 1
    • 2
  1. 1.Rosalind Russell Arthritis Research Laboratory, Medical ServiceSan Francisco General HospitalSan FranciscoUSA
  2. 2.Department of MedicineUniversity of CaliforniaSan FranciscoUSA

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