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Regulation of Human Leukocyte Function by Lipoxygenase Products of Arachidonic Acid

  • Frank H. Valone
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 14)

Abstract

Arachidonic acid released from membrane phospholipids undergoes oxygenation by two distinct pathways that differ in terms of both their products and their susceptibility to regulation by biological and pharmacological agents(Fig. 1). The cyclooxygenase pathway yields unstable endoperoxide intermediates that undergo spontaneous or enzymatic conversion to a variety of products including pro staglandins, pro st acyclin , and thromboxanes. Oxygenation of arachidonic acid by the lipoxygenase pathway generates a series of unstable hydroperoxy-eicosatetraenoic acids (OOHETES or HPETES), of which 5-OOHETE is quantitatively predominant in several types of leukocytes, 12-OOHETE is the major product in platelets, and 11-OOHETE and 5-OOHETE in rabbit alveolar macrophages (Borgeat and Samuelsson, 1979a; Goetzl and Sun, 1979; Valone et al., 1980).

Keywords

Arachidonic Acid Polymorphonuclear Leukocyte Lipoxygenase Pathway Lipoxygenase Product Eicosatetraenoic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Frank H. Valone
    • 1
  1. 1.Cancer Research InstituteUniversity of California School of MedicineSan FranciscoUSA

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