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The Neutrophil N-Formyl Peptide Receptor: Dynamics of Ligand-Receptor Interactions and Their Relationship to Cellular Responses

  • Larry A. Sklar
  • Algirdas J. Jesaitis
  • Richard G. Painter
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 14)

Abstract

The N-formyl peptides, as a class, evoke in neutrophils in vitro an array of responses that mimic the biological functions of these cells in the inflammatory process. Because these peptides can be prepared synthetically, it has been possible to correlate extensively the structure-function relationships of a variety of amino acid sequences in both stimulatory and inhibitory peptides. Moreover,.this diversity in available sequences has permitted the development not only of numerous radiolabeled ligands, but of photoaffinity and fluorescent molecules as well. During the short period since N-formyl-methionyl peptides were first identified as chemoattractants derived from bacteria, the N-formyl peptides receptor has been catapulted into a position of prominence as a model, not only for studies of neutrophil stimulation but for receptor-mediated cell stimulation in general.

Keywords

Human Neutrophil Receptor Occupancy Peptide Receptor Formyl Peptide Receptor Human Polymorphonuclear Leukocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Larry A. Sklar
    • 1
  • Algirdas J. Jesaitis
    • 1
  • Richard G. Painter
    • 1
  1. 1.Department of ImmunologyScripps Clinic and Research FoundationLa JollaUSA

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