What Can We Learn from Marine Invertebrates to be Used as Complementary Antibiotics?
Several biotechnology start-ups are engaged in developing novel antibiotics using antimicrobial peptides as templates. The pioneer was Magainin Pharmaceuticals from Philadelphia (PA USA) in the early 1990s with Pexiganan®, derived from frog skin magainin, but with little success. Another North-American company, Intrabiotics Pharmaceuticals from Mountain View (CA) developed Iseganan®, a synthetic analogue to pig protegrin. Micrologix Biotech from Vancouver (BC Canada) developed several linear antimicrobial peptides, particularly against resistant Staphylococcus aureus. EntoMed from Strasbourg (France) was the first company to use insect (a non revealed tropical butterfly) antimicrobial peptides to fight fungal infections due to Candida and Aspergillus in immunologically compromised patients. Anti Gram+ bacterial activity, particularly Staphylococcus, have also been analyzed. Recently, SelectBiotics from Montpellier (France) has become interested in the peptides produced by several bacterial species to protect themselves from other microorganisms.
KeywordsCysteine Proline Bacillus Beach Disulfide
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