Oxygen Diffusion Coefficients for Blood Flowing down a Wetted-Wall Column
Using a wetted-wall column one meter in length to produce a falling film, whole blood was oxygenated with a countercurrently flowing stream of pure oxygen. From the derived transport equation describing this operation, overall diffusion coefficients were calculated for oxygen in whole blood. For a l-inch diameter column, the arithmetic average value for the diffusion coefficient was 2.07 × 10−5 cm2/sec in the 87 to 96 per cent saturation range. For the 1/2-inch column, the average diffusion coefficient was 2.13 × 10−5 cm2/sec in the 72 to 96 per cent range. An arithmetic average of all the data for both columns in the 72 to 96 per cent range was 2.10 × 10−5 cm2/sec at 30°C with a standard deviation of 0.42 × 10−5 cm2/sec.
Limitations of the model used are discussed and a brief review of other work in this area is presented.
KeywordsDioxide Heparin Carbon Monoxide Resis
Unable to display preview. Download preview PDF.
- 1.Benis, A.M., Sc.D. Thesis, Massachusetts Institute of Technology, 1964.Google Scholar
- 2.Collins, R.E., “Transport of Gases Through Hemoglobin Solutions”, Science 133., 1593 (1961).Google Scholar
- 6.Hartridge, H. and F.J.W. Roughton, “The Rate of Distribution of Dissolved Gases between the Red Blood Corpuscle and Its Fluid Environment”, J. Physiol. 62, 232 (1927).Google Scholar
- 8.Hesselberth, J.F., Research in Progress, University of Cincinnati, Cincinnati, Ohio, 1966.Google Scholar
- 9.Kreuzer, F. and W.Z. Yahr, Influence of Red Cell Membrane on Diffusion of Oxygen, J. Appl. Physiol., 15, 1117 (1960).Google Scholar
- 10.Marx, T.I., W.E. Snyder, A.D. St. John, and C.E. Moeller, “Diffusion of Oxygen into a Film of Whole Blood”, J. Appl. Physiol. 15, 1123, (1960).Google Scholar
- 11.Menke, R.C., Research in Progress, University of Cincinnati, Cincinnati, Ohio, 1966Google Scholar
- 12.Miller, C.J., “Mass Transfer of Oxygen into Blood Using a Wetted-Wall Column”, University of Cincinnati, M.S. Thesis, 1965.Google Scholar
- 13.Rosenthal, T.B., “The Effect of Temperature on the pH of Blood and Plasma in Vitro”, J. Biol. Chem., 73, 25 (1948).Google Scholar
- 15.Roughton, F.J.W., Progress in Biophysics and Biophysical Chemistry, 9., 55 (1959)Google Scholar
- 17.Severinghaus, J.W., “Oxyhemoglobin Dissociation Curve,” J. Appl. Physiol., 12, 485 (1964).Google Scholar
- 21.Yoshida, F. and Oshima, N., J. Appl. Physiol. 21 (3), 915 (1966).Google Scholar