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Transport Functions of the Blood-Retinal Barrier System and the Micro-Environment of the Retina

  • Laszlo Z. Bito
  • C. Jean DeRousseau

Abstract

As we shall see, the blood-retinal barrier system consists of at least three topographically, morphologically and functionally distinct components. Experimental approaches to the demonstration and definition of ocular transport processes across various regions of this barrier system are manifold, and in most cases no single approach can prove the existence of transport. Yet, it appears that with the exception of dissolved gases, virtually all normal solutes and drugs enter into or are removed from the intraocular fluids (IOFs), including the extracellular fluids (ECFs) of the retina, by facilitated or active transport processes across the blood-aqueous and blood-retinal barriers. A complete review of this field is clearly beyond the scope of this article. We shall, therefore, focus on principles rather than details, and will present data and references which are illustrative rather than inclusive.

Keywords

Retinal Pigment Epithelium Aqueous Humor Transport Function Ciliary Epithelium Posterior Chamber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Laszlo Z. Bito
    • 1
  • C. Jean DeRousseau
    • 1
  1. 1.Laboratory of Ocular Physiology, Research Division, Department of Ophthalmology College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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