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Cerebral Endothelium, Blood-Brain-Barrier and the Astrocyte Membrane

  • K. Dorovini-Zis
  • J. J. Anders
  • M. W. Brightman

Abstract

The manner in which protein crosses from blood to the extracellular clefts of the brain, when the barrier to such passage has been disrupted, has not been fully elucidated. The barrier, which maintains a sharp gradient between the high concentration of protein within the blood and the very low amount in the extracellular fluid of the cerebral parenchyma, is endothelial. The occlusion of the extracellular clefts between adjacent endothelial cells by successive belts of tight junctions together with the absence of vesicular transfer ensure that proteins do not cross the cerebral vessel (Reese and Karnovsky, 1967). The degree of occlusion is complete with regard to protein and substances as small as ionic lanthanium (La3+) (Bouldin and Krigman, 1975), which has a diameter of about 0.9 nm.

Keywords

Tight Junction Basal Lamina Cerebral Vessel Lanthanum Chloride Ionic Lanthanum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • K. Dorovini-Zis
    • 1
  • J. J. Anders
    • 1
  • M. W. Brightman
    • 1
  1. 1.Laboratory of Neuropathology and Neuroanatomical Sciences National Institute of Neurological and Communicative Diseases and StrokeNational Institutes of HealthBethesdaUSA

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