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Targeting Pulmonary Endothelium

  • Vladimir R. Muzykantov
Chapter

Abstract

The pulmonary endothelium maintains vital functions including control of thrombosis, inflammation, vascular permeability and blood pressure. Endothelial cells in the lung blood vessels are vulnerable to oxidative, thrombotic and inflammatory insults and represent an important target for therapies. However, despite the huge surface and high accessibility of this target to blood, only a minor fraction of circulating therapeutics is adequately delivered to the pulmonary endothelium. Effective, safe and specific delivery of drugs, enzymes and genetic materials to this target may help to improve current modalities in therapies and prophylaxis of pulmonary hypertension, oxidative stress, embolism, edema, acute lung injury, and other disease conditions.

Keywords

Acute Lung Injury Pulmonary Vasculature Intracellular Delivery Pulmonary Endothelium Candidate Determinant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Vladimir R. Muzykantov
    • 1
  1. 1.Department of PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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