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Targeting Mitochondria

  • Volkmar Weissig
  • Gerard D’ Souza
  • Vladimir P. Torchilin
Chapter

Abstract

The field of mitochondrial research is currently one of the fastest growing disciplines in biomedicine. During the last decade alone, more than 26,000 articles on mitochondria have been published in over 1000 scientific journals. What brings mitochondria into the limelight of the scientific community? Since the end of the ‘80s, a series of key discoveries have been made which have rekindled the scientific interest in this long-known cell organelle. It has become increasingly evident that mitochondrial dysfunction contributes to a variety of human disorders, ranging from neurodegenerative and neuromuscular diseases, obesity, and diabetes to ischemia-reperfusion injury and cancer. Moreover, since the middle of the ‘90s, mitochondria, the “power houses” of the cell, have also become accepted as the “motor of cell death” (1), which reflects their increasingly acknowledged key role during apoptosis (programmed cell death).

Keywords

Mitochondrial Membrane Mitochondrial Matrix Intermembrane Space Death Receptor Pathway Advance Drug Delivery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Volkmar Weissig
    • 1
  • Gerard D’ Souza
    • 1
  • Vladimir P. Torchilin
    • 1
  1. 1.Bouve College of Health Sciences, School of Pharmacy, Department of PharmaceuticsNortheastern UniversityBostonUSA

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