Ligand-Mediated Gastrointestinal Targeting
This chapter will describe the rationale for drug targeting to the gastrointestinal (GI) tract, why it is important, and what the objectives of such targeting are. The approaches used to achieve these targeting objectives using ligands will be considered and discussed in detail. It it is important to consider some of the pharmaceutical issues involved, such as the type of vehicles to which ligands can be usefully attached. It should be stressed that at the current time, much of the work in this area is theoretical and experimental, with studies in cell culture systems or animals, and has yet to be transferred to man, let alone into pharmaceutical products on the market. In many cases, costs and regulatory considerations may make it prohibitive for the pharmaceutical industry to adopt some of the most interesting ideas emanating from the research laboratories.
KeywordsWheat Germ Agglutinin Oral Vaccine Oral Drug Delivery Therapeutic Peptide Sulfhydryl Compound
Unable to display preview. Download preview PDF.
- 1.J. Pappo, T.H. Ermak and H.J. Steger. Monoclonal antibody-directed targeting of fluorescent polystyrene microspheres to Peyer’s patch M cells. Immunology 73: 277–280 (1991).Google Scholar
- 2.J.F. Woodley and B. Naisbett. The potential of lectins for delaying the intestinal transit of drugs. Proc. Int. Symp. Contr. Rel. Bioact. Mater. 15: 125–126 (1988).Google Scholar
- 5.Lehr, C.-M,. A. Pustzai. “The potential of bioadhesive lectins for the delivery ofGoogle Scholar
- peptide and protein drugs to the gastrointestinal tract.“ In Lectins:Biomedicalperspectives,A.Pusztai, S.Bardocz, ed. London and Bristol: Taylor and Francis, 1995.Google Scholar
- 11.S. Wrôblewski, P. Kopéckova, B. Rihovâ and J. Kope6ek. Lectin-HPMA copolymer conjugates-drug carriers for gastrointestinal tract targeting. Proc. Int. Symp. Contr. Rel. Bioact. Mater. 25: 768–769 (1998).Google Scholar
- 14.E.C. Lavelle. Targeted delivery of drugs to the gastrointestinal tract. Crit. Rev. Ther. Drug Car. Syst. 18: 341–386 (2001).Google Scholar
- 16.D. Ayelet, P. Kopeckovâ, T. Minko, A. Rubinstein and J. Kope6ek. The involvement of endogenous lectins in mediating the antitumor activity of targetable HPMA copolymer-doxorubicin conjugates in human colon adenocarcinoma and hepatoma cells. Pharm. Res. In press: (2002).Google Scholar
- 17.J. Alsenz, G.J. Russell-Jones, S. Westwood, B. Levet-Trafit and P.C. de Smidt. Oral absorption of peptides through the cobalamin (vitamin B 12) pathway in the rat intestine. J. Cont. Rel. 17: 825–832 (2000).Google Scholar