Targeting Brain Trauma and Stroke

  • Margaret A. Petty
  • Eng H. Lo


Acute stroke can be classified as ischemic, hemorrhagic, or both and result in the occurrence of multiple pathophysiological processes. These pathophysiological events develop over the subsequent hours to days, as the original core of the infarct develops into the surrounding penumbral area (1, 2). Initial cell death results from the deprivation of blood supply to the brain. However, a significant portion of the brain damage occurs later when secondary deleterious mechanisms come into play (2). The recent progress made in defining the mechanisms involved in the pathophysiology of stroke will probably lead to the identification of new strategies for intervention in the ischemic cascade. Therefore, it becomes increasingly important to initially consider how these new therapeutics may be delivered into the target tissue in brain and secondly to speculate on new strategies that would target ischemic brain tissue.


Blood Brain Barrier Middle Cerebral Artery Occlusion Focal Cerebral Ischemia Cereb Blood Flow Human Umbilical Cord Blood 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Margaret A. Petty
    • 1
  • Eng H. Lo
    • 2
  1. 1.CNS PharmacologyAventis Pharmaceuticals Inc.BridgewaterUSA
  2. 2.Neuroprotection Research Laboratory, Dept. of Neurology and RadiologyMassachusetts General Hospital, and Program in Neuroscience, Harvard Medical SchoolUSA

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