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Enhanced Permeability and Retention (EPR) Efect: Basis for Drug Targeting to Tumor

  • Hiroshi Maeda
Chapter

Abstract

Tumor vascular permeability is becoming increasingly important in tumor biology because of its critical role in tumor growth and perhaps in metastasis, as well as in the selective delivery of anticancer agents, particularly macromolecular compounds, to tumors (see Refs. 1–5 for reviews). This issue of vascular permeability is significant primarily in tumorous tissues (and in inflammatory tissues). Macromolecular (or polymeric) drugs are of interest because they are in the class of substances manifesting enhanced extravasation in tumor tissue. The tumor-selective phenomenon has been characterized and termed the enhanced permeability and retention (EPR) effect of macromolecules and lipidic particles (2–4). One can best take advantage of this unique EPR effect for tumor-targeted delivery of drugs. Thus, polymeric drugs and microparticles, including micellar compounds or liposomes, can be delivered with greater selectivity to tumors because of the EPR effect.

Keywords

Drug Target Evans Blue Polymeric Drug Metastatic Liver Cancer HPMA Copolymer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Hiroshi Maeda
    • 1
  1. 1.Department of MicrobiologyKumamoto University School of MedicineKumamotoJapan

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