Quantification of the Microcirculatory Response to Freezing
Extensive clinical and experimental data verify that freezing and thawing processes can produce trauma and necrosis in living tissue. The primary effects associated with this phenomena have been summarized in several recent reviews1-3. The response of tissue to freezing injury is intimately related to modifications produced in the functional state of the localized circulatory system. Although subzero tissue temperatures are requisite to freezing insult, they may not be damaging per se; concommitant vascular collaspe may be the ultimate factor in tissue death. For example, skin, frozen to the extent that if left in place it will inevitably die, has been shown to survive if transplanted to a normal vascular bed4,5. Thus, under the proper conditions, damage caused by freezing can be reversed if adequate blood circulation is maintained.
KeywordsGray Level Microcirculatory Response Macromolecular Leakage Copy Device Interstitial Transport
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