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Abstract

The primary structure of a protein is defined as the sequence of the amino acid residues in its polypeptide chain(s). This definition will be expanded here to include all covalent structures such as cross-links, attached carbohydrates, and modifications to amino acid side chains. However, it should be remembered that the sequence of amino acids in α-amino peptide linkage is the product of a structural gene, while all other aspects of covalent structure result from posttranslational events. Thse two aspects of covalent structure require that two quite different concepts be invoked in understanding the biological regulation of structure—function relationships.

Keywords

Skin Collagen Cyanogen Bromide Cleavage Cyanogen Bromide Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Karl. A. Piez
    • 1
  1. 1.Laboratory of Biochemistry, National Institute of Dental ResearchNational Institutes of HealthBethesdaUSA

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