Abstract
Modern organic synthesis has been advanced in large part through an increased understanding of solvent effects and by the development of sophisticated reaction catalysts. However, some of the best-designed catalysts, i.e., naturally-occurring enzymes, have been generally excluded from use in organic synthesis because of their perceived requirement for a totally aqueous reaction solvent. Over recent years, reports documenting the ability of enzymes to function under nearly anhydrous conditions may reconcile this dilemma1–8 and lead to a significant expansion of the industrial applications of enzymes.
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References
A. Zaks and A. M. Klibanov, Proc. Nad. Acad. Sci. USA 82, 3192 (1985).
B. Cambou and A. M. Klibanov, J. Am. Chem. Soc. 106, 2687 (1984).
R. Kazandjian, J. S. Dordick, and A. M. Klibanov, Biotechnol. Bioeng. 28, 417 (1986).
A. Zaks and A. M. Klibanov, Science 224, 1249 (1984).
T. Yoshimoto, K. Takahashi, H. Nishimura, A. Ajima, Y. Tamaura, and Y. Inada, Biotechnol. Lett. 6 (6), 337 (1984).
K. Takahashi, A. Ajima, T. Yoshimoto, and Y. Inada, Biochem. Biophys. Res. Commun. 125 (2), 761 (1984).
A. M. Klibanov, Chemtech. 16, 354 (1986).
C. Laane, S. Boeren, R. Hilhorst, and C. Veeger, (1987); Stud. Org. Chem. 29, 65 (1987).
J. S. Deetz and J. D. Rozzell, The World Biotech. Report, Vol. 2, Part 3, 25 (1986).
J. Grunwald, B. Wirz, M. P. Scollar, and A. M. Klibanov, J. Am. Chem. Soc. 108, 6732 (1986).
J. S. Deetz and J. D. Rozzell, Trends in Biotechnol. 6, 15 (1988).
T. Kawamoto, A. Aoki, K. Sonomoto, and A. Tanaka, J. Ferment. Bioeng. 67, 361 (1989).
D. S. Clark, L. Creagh, P. Skerker, M. Guinn, J. Prausnitz, and H. Blanch, ACS Symp. Ser. 392, 104 (1989).
P. V. Halling and A. R. MaCrae, European Patent Application number 0, 064, 855 (1982).
A. M. Klibanov and G. M. Kirchner, US Patent 4, 601, 987 (1986).
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© 1991 Springer Science+Business Media New York
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Deetz, J.S., Rozzell, J.D. (1991). Catalysis by Alcohol Dehydrogenases in Organic Solvents. In: Dordick, J.S. (eds) Biocatalysts for Industry. Topics in Applied Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4597-9_9
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DOI: https://doi.org/10.1007/978-1-4757-4597-9_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-3216-7
Online ISBN: 978-1-4757-4597-9
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