Nocardia asteroides as an Invasive, Intracellular Pathogen of the Brain and Lungs

Part of the Subcellular Biochemistry book series (SCBI, volume 33)


This genus is defined morphologically as gram-positive, partially acid-fast, branching filamentous bacteria that divide by fragmentation. They are strictly aerobic, mycolic acid containing actinomycetes phylogenetically related to Mycobacterium, Corynebacterium, Rhodococcus, Gordona, and Tsukamurella (Wilson et al., 1998). Twelve species comprise this genus; however, the type species, Nocardia asteroides, has been most frequently studied (Beaman, B. and L. Beaman, 1994). This species is phenotypically diverse, and many investigators believe that the N. asteroides complex consists of at least 5 to 6 distinct groups. Some of these have now been assigned species status. Thus, the N. asteroides complex currently includes N. asteroides, N. farcinica, and N. nova. It is likely that additional species will be created from further subdivision of this taxon. Since routine laboratory identification does not differentiate these species, most reports of infections due to N. asteroides represent the total complex and underestimate infections due to individual members such as N. farcinica and N. nova (Workman et al., 1998).


Intracellular Pathogen Mycolic Acid Stationary Phase Cell Pulmonary Epithelial Cell Nocardia Asteroides 
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© Springer Science+Business Media New York 2000

Authors and Affiliations

  1. 1.Department of Medical Microbiology and ImmunologyUniversity of California School of MedicineDavisUSA

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