Abstract
Streptococcus pneumoniae remains one of the world’s leading invasive human pathogens causing pneumonia, sepsis, and meningitis. Infants and toddlers between 18 months and 4 years of age are particularly susceptible (Tuomanen et al., 1995). Virtually every child up to age 5 will experience pneumococcal otitis media while the incidence of pneumonia (1000 per 100,000 inhabitants) and meningitis (10 per 100,000 inhabitants) is much lower. However, pneumococcal meningitis continues to be a serious threat with a mortality of 25% and a morbidity of 80% in children. Despite the development of novel antibiotics, the mortality from pneumococcal meningitis has not changed significantly during the last 20 years. Taken together with increasing antibiotic resistance among pneumococci, it has become imperative to improve our understanding of the mechanisms by which this bacterium colonizes, invades and kills its victims. The development of vaccines and novel adjunctive drugs targeting defined pneumococcal virulence determinants is a crucial goal of current research.
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References
Andersson, B., Dahmen, J., Frejg, T., Leffler, H., Magnusson, G., Noori, G., and Svanborg, E.C., 1983, Identification of an active disaccharide unit of a glycoconjugate receptor for pneumococci attaching to human pharyngeal epithelial cells, J. Exp. Med. 158: 559–570.
Barthelson, R., Mobasseri, A., Zopf, D., and Simon, P., 1998, Adherence of Streptococcus pneumoniae to respiratory epithelial cells is inhibited by sialylated oligosaccharides, Infect. Immun. 66: 1439–1444.
Birkness, K., Swisher, B., White, E., Long, E., Ewing, E., and Quinn, E, 1995, A tissue cultre bilayer model to study the passage of Neisseria meningitidis, Infect.. Immun. 63: 402–409.
Cheng, Q., Campbell, E., Naughton, A., Johnson, S., and Masure, H., 1997, The corn locus con trols genetic transformation in Streptococcus pneumoniae, Mol. Microbiol. 23: 683–692.
Cundell, D., and Tuomanen, E., 1994, Receptor specificity of adherence of Streptococcus pneumoniae to human type II pneumocytes and vascular endothelial cells in vitro, Microb. Pathog. 17: 361–374.
Cundell, D., Gerard, N., Gerard, C., Idanpaan-Heikkila, I., and Tuomanen, E., 1995, Streptococcus pneumoniae anchors to activated eukaryotic cells by the receptor for platelet activating factor, Nature 377: 435–438.
Garcia Rodriguez, C., Cundell, D., Tuomanen, E., Kolakowski, L.J., Gerard, C., and Gerard, N., 1995, The role of N-glycosylation for functional expression of the human platelet-activating factor receptor. Glycosylation is required for efficient membrane trafficking, J. Biol. Chem. 270: 25178–25184.
Geelen, S., Battacharyya, C., and Tuomanen, E., 1993, Cell wall mediates pneumococcal attachment and cytopathology to human endothelial cells, Infect. Immun. 61: 1538–1543.
Gerard, N., and Gerard, C., 1994, Receptor-dependent internalization of platelet-activating factor, J. Immunol. 152: 793–800.
Gray, B., and Dillon, H., 1986, Clinical and epidemiologic studies of pneumococcal infection in children, Pediatr. Infect. Dis. 5: 201–207.
Guenzi, R., and Hakenbeck, R., 1995, Genetic competence and a two component regulatory system in pneumococci, Mol. Microbiol. 12: 505–515.
Hammerschmidt, S., Talay, S., Brandtzaeg, P., and Chhatwal, G., 1997, SpsA, a novel pneumococcal surface protein with specific binding to secretory immunoglobulin A and secretory component, Mol. Microbiol. 25: 1113–1124.
Havarstein, L., Gaustad, R, Nes, I., and Morrison, D., 1996, Identification of the streptococcal competence pheromone receptor, Mol. Mcirobiol. 21: 965–971.
Idanpaan-Heikkila, I., Simon, R, Cahill, C., Sokol, K., and Tuomanen, E., 1997, Oligosaccharides interfere with the establishment and progression of experimental pneumococcal pneumonia, J. Infect. Dis. 176: 704–712.
Kostrzynska, M., and Wadstrom, T., 1992, Binding of laminin, type IV collagen, and vitronectin by Streptococcus pneumoniae, Zbl. Bakt. 277: 80–83.
Krivan, H.C., Roberts, D.D., and Ginsburg, V., 1988, Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence GalNAc31–4Gal found in some glycolipids, Proc. Natl. Acad. Sci. USA 85: 6157–6161.
Kunz, D., Gerard, N., and Gerard, C., 1992, The human leukocyte platelet activating factor receptor, J. Biol. Chem. 267: 9101–9106.
McDaniel, L.S., Sheffield, J.S., Delucchi, R, and Briles, D.E., 1991, PspA, a surface protein of Streptococcus pneumoniae, is capable of eliciting protection against pneumococci of more than one capsular type, Infect. Immun. 59: 222–228.
Mitchell, T., and Andrew, R, 1997, Biological properties of pneumolysin, Microb. Drug Resistance 3: 19–26.
Nizet,V., Kim, K., Stins, M., Jonas, M., Chi, E.Y., Nguyen, D., and Rubens, C., 1997, Invasion of brain microvascular endothelial cells by Group B streptococci, Infect. Immun. 65: 5074–5081.
Patrick, D., Betts, J., Fery, E., Prameya, R., Dorovini-Zis, K., and Finaly, B., 1992, Haemophilus influenzae lipopolysaccharide disrupts confluent monolayers of bovine brain endothlial cells via a serum-dependent cytotoxic pathway, J. Infect. Dis. 165: 865–872.
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Ring, A., Tuomanen, E. (2000). Host Cell Invasion by Streptococcus pneumoniae . In: Oelschlaeger, T.A., Hacker, J. (eds) Bacterial Invasion into Eukaryotic Cells. Subcellular Biochemistry, vol 33. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4580-1_6
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DOI: https://doi.org/10.1007/978-1-4757-4580-1_6
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