Advertisement

Host Cell Invasion by Streptococcus pneumoniae

  • Axel Ring
  • Elaine Tuomanen
Part of the Subcellular Biochemistry book series (SCBI, volume 33)

Abstract

Streptococcus pneumoniae remains one of the world’s leading invasive human pathogens causing pneumonia, sepsis, and meningitis. Infants and toddlers between 18 months and 4 years of age are particularly susceptible (Tuomanen et al., 1995). Virtually every child up to age 5 will experience pneumococcal otitis media while the incidence of pneumonia (1000 per 100,000 inhabitants) and meningitis (10 per 100,000 inhabitants) is much lower. However, pneumococcal meningitis continues to be a serious threat with a mortality of 25% and a morbidity of 80% in children. Despite the development of novel antibiotics, the mortality from pneumococcal meningitis has not changed significantly during the last 20 years. Taken together with increasing antibiotic resistance among pneumococci, it has become imperative to improve our understanding of the mechanisms by which this bacterium colonizes, invades and kills its victims. The development of vaccines and novel adjunctive drugs targeting defined pneumococcal virulence determinants is a crucial goal of current research.

Keywords

Sialic Acid Streptococcus Pneumoniae Brain Endothelial Cell Pneumococcal Meningitis Brain Microvascular Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Andersson, B., Dahmen, J., Frejg, T., Leffler, H., Magnusson, G., Noori, G., and Svanborg, E.C., 1983, Identification of an active disaccharide unit of a glycoconjugate receptor for pneumococci attaching to human pharyngeal epithelial cells, J. Exp. Med. 158: 559–570.PubMedCrossRefGoogle Scholar
  2. Barthelson, R., Mobasseri, A., Zopf, D., and Simon, P., 1998, Adherence of Streptococcus pneumoniae to respiratory epithelial cells is inhibited by sialylated oligosaccharides, Infect. Immun. 66: 1439–1444.PubMedGoogle Scholar
  3. Birkness, K., Swisher, B., White, E., Long, E., Ewing, E., and Quinn, E, 1995, A tissue cultre bilayer model to study the passage of Neisseria meningitidis, Infect.. Immun. 63: 402–409.PubMedGoogle Scholar
  4. Cheng, Q., Campbell, E., Naughton, A., Johnson, S., and Masure, H., 1997, The corn locus con trols genetic transformation in Streptococcus pneumoniae, Mol. Microbiol. 23: 683–692.PubMedCrossRefGoogle Scholar
  5. Cundell, D., and Tuomanen, E., 1994, Receptor specificity of adherence of Streptococcus pneumoniae to human type II pneumocytes and vascular endothelial cells in vitro, Microb. Pathog. 17: 361–374.PubMedCrossRefGoogle Scholar
  6. Cundell, D., Gerard, N., Gerard, C., Idanpaan-Heikkila, I., and Tuomanen, E., 1995, Streptococcus pneumoniae anchors to activated eukaryotic cells by the receptor for platelet activating factor, Nature 377: 435–438.PubMedCrossRefGoogle Scholar
  7. Garcia Rodriguez, C., Cundell, D., Tuomanen, E., Kolakowski, L.J., Gerard, C., and Gerard, N., 1995, The role of N-glycosylation for functional expression of the human platelet-activating factor receptor. Glycosylation is required for efficient membrane trafficking, J. Biol. Chem. 270: 25178–25184.PubMedCrossRefGoogle Scholar
  8. Geelen, S., Battacharyya, C., and Tuomanen, E., 1993, Cell wall mediates pneumococcal attachment and cytopathology to human endothelial cells, Infect. Immun. 61: 1538–1543.PubMedGoogle Scholar
  9. Gerard, N., and Gerard, C., 1994, Receptor-dependent internalization of platelet-activating factor, J. Immunol. 152: 793–800.PubMedGoogle Scholar
  10. Gray, B., and Dillon, H., 1986, Clinical and epidemiologic studies of pneumococcal infection in children, Pediatr. Infect. Dis. 5: 201–207.CrossRefGoogle Scholar
  11. Guenzi, R., and Hakenbeck, R., 1995, Genetic competence and a two component regulatory system in pneumococci, Mol. Microbiol. 12: 505–515.CrossRefGoogle Scholar
  12. Hammerschmidt, S., Talay, S., Brandtzaeg, P., and Chhatwal, G., 1997, SpsA, a novel pneumococcal surface protein with specific binding to secretory immunoglobulin A and secretory component, Mol. Microbiol. 25: 1113–1124.PubMedCrossRefGoogle Scholar
  13. Havarstein, L., Gaustad, R, Nes, I., and Morrison, D., 1996, Identification of the streptococcal competence pheromone receptor, Mol. Mcirobiol. 21: 965–971.Google Scholar
  14. Idanpaan-Heikkila, I., Simon, R, Cahill, C., Sokol, K., and Tuomanen, E., 1997, Oligosaccharides interfere with the establishment and progression of experimental pneumococcal pneumonia, J. Infect. Dis. 176: 704–712.PubMedCrossRefGoogle Scholar
  15. Kostrzynska, M., and Wadstrom, T., 1992, Binding of laminin, type IV collagen, and vitronectin by Streptococcus pneumoniae, Zbl. Bakt. 277: 80–83.Google Scholar
  16. Krivan, H.C., Roberts, D.D., and Ginsburg, V., 1988, Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence GalNAc31–4Gal found in some glycolipids, Proc. Natl. Acad. Sci. USA 85: 6157–6161.PubMedCrossRefGoogle Scholar
  17. Kunz, D., Gerard, N., and Gerard, C., 1992, The human leukocyte platelet activating factor receptor, J. Biol. Chem. 267: 9101–9106.PubMedGoogle Scholar
  18. McDaniel, L.S., Sheffield, J.S., Delucchi, R, and Briles, D.E., 1991, PspA, a surface protein of Streptococcus pneumoniae, is capable of eliciting protection against pneumococci of more than one capsular type, Infect. Immun. 59: 222–228.PubMedGoogle Scholar
  19. Mitchell, T., and Andrew, R, 1997, Biological properties of pneumolysin, Microb. Drug Resistance 3: 19–26.CrossRefGoogle Scholar
  20. Nizet,V., Kim, K., Stins, M., Jonas, M., Chi, E.Y., Nguyen, D., and Rubens, C., 1997, Invasion of brain microvascular endothelial cells by Group B streptococci, Infect. Immun. 65: 5074–5081.Google Scholar
  21. Patrick, D., Betts, J., Fery, E., Prameya, R., Dorovini-Zis, K., and Finaly, B., 1992, Haemophilus influenzae lipopolysaccharide disrupts confluent monolayers of bovine brain endothlial cells via a serum-dependent cytotoxic pathway, J. Infect. Dis. 165: 865–872.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Axel Ring
    • 1
  • Elaine Tuomanen
    • 1
  1. 1.Department of Infectious DiseasesSt. Jude Children’s Research HospitalMemphisUSA

Personalised recommendations