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E. coli Invasion of Brain Microvascular Endothelial Cells as a Pathogenetic Basis of Meningitis

  • Kwang Sik Kim
Part of the Subcellular Biochemistry book series (SCBI, volume 33)

Abstract

Bacterial meningitis still results in a high mortality and morbidity despite advances in antimicrobial chemotheraphy and supportive care (Durand et al., 1993; Unhanand et al., 1993). Both clinical and experimental data indicate limited efficacy with antimicrobial chemotherapy alone (Kim, 1985; McCracken et al., 1984). A major contributing factor is the incomplete understanding of the pathogenesis and pathophysiology associated with the bacterial meningitis. For example, most cases of bacterial meningitis develop as a result of hematogenous spread, but it is not clear how circulating bacteria cross the blood-brain barrier. We have utilized E.coli as a paradigm to examine how circulating bacteria traverse the blood-brain barrier. In addition, E. coli is the most common gram-negative bacterium that causes meningitis, particularly during the neonatal period. Our investigations have become feasible with the availability of both in vitro and in vivo models of the blood-brain barrier.

Keywords

Focal Adhesion Kinase Human Umbilical Vein Endothelial Cell Bacterial Meningitis Brain Microvascular Endothelial Cell Human Brain Microvascular Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Kwang Sik Kim
    • 1
  1. 1.Division of Infectious DiseasesChildrens Hospital Los AngelesLos AngelesUSA

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