Abstract
Infections caused by organisms of the genera mycobacteria are responsible for a great percentage of yearly deaths dues to infectious diseases. Tuberculosis is a widespread infection caused by Mycobacterium tuberculosis. It is transmitted mainly as an airborne infection. M. bovis is found in cattle and it is transmitted to humans via contaminated milk and dairy products. Infections caused by Mycobacterium avium complex can cause localized disease usually in patients with underlying lung disease as well as disseminated disease in individuals with immunosuppression or Acquired Immunodeficiency Syndrome (AIDS). According to the World Health Organization, infections caused by mycobacteria will rise to 12 million cases annually by the year 2000.
Keywords
- Intestinal Mucosa
- Intestinal Epithelial Cell
- Alveolar Epithelial Cell
- Mycobacterium Avium
- Mycobacterium Avium Complex
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Abou-Zeid, C., Ratliff, T.L., Wiker, H.G., Harboe, M., Bennedsen, J., and Rook, G.A.W., 1988, Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis, Infect. Immun. 56: 3046–3051.
Adam, T., Arpim, M., Prevost, M.C., Gounon, P., and Sansonetti, P.J., 1995, Cytoskeletal rearrangements and the functional role of T-plastin during entry of Shigella flexneri into HeLa cells, J. Cell Biot 129: 367–381.
Barker, J., Lambert, P.A., and Brown, M.R.W., 1993, Influence of intramoebic and other growth conditions on the surface properties of Legionella pneumophila, Infect. Immun. 62: 3254–3261.
Benson, C.A., and Ellner, J.J., 1993, Mycobacterium avium complex infection and AIDS: Advances in theory and practice, Clin. Infect. Dis. 17: 7–20.
Bermudez, L.E., and Goodman, J., 1996, Mycobacterium tuberculosis invades and replicates within type II alveolar cells, Infect. Immun. 64: 1400–1406.
Bermudez, L.E., and Goodman, J., 1998, Mycobacterium avium attachment and invasion of intestinal epithelial cells is associated with cytoskeleton rearrangement, submitted.
Bermudez, L.E., Parker, A., and Goodman, J., 1997a, Growth within macrophages increases the efficiency of Mycobacterium avium to invade other macrophages by complement receptor independent pathway, Infect. Immun. 65: 1916–1922.
Bermudez, L.E., Petrofsky, M., and Goodman, J., 1997b, Exposure to low oxygen tension and increased osmolarity enhance the ability of Mycobacterium avium to enter intestinal epithelial (HT-29) cells, Infect. Immun. 65: 3768–3772.
Bermudez, L.E., Petrofsky, M., Kolonoski, P., and Young, L.S., 1992, An animal model of Mycobacterium avium complex disseminated infection after colonization of the intestinal tract, J. Infect. Dis. 165: 75–79.
Bermudez, L.E., Shelton, K., and Young, L.S., 1995, Comparison of the ability of M. avium, M. smegmatis, and M. tuberculosis to invade and replicate within HEp-2 epithelial cells, Tubercle Lung Dis. 76: 240–247.
Bermudez, L.E., and Young, L.S., 1994, Factors affecting invasion of HT-29 and HEp-2 epithelial cells by organisms of the Mycobacterium avium complex, Infect. Immun. 62: 2021–2026.
Bloom, B.R., 1994, Tuberculosis: Pathogenesis, protection and control, ASM Press. Washington, D.C.
Bodmer, T., Miltzer, E., and Bermudez, L.E., 1998, Mycobacterium avium resists exposure to acidic conditions of the stomach, a property that is enhanced by re-adaptation to hypoosmolarity, Submitted.
Cirillo, J., Falkow, S., Tompkins, L., and Bermudez, L.E., 1997, Growth of Mycobacterium avium within environmental amoeba enhances virulence, Infect. Immun. 65: 3759–3769.
Cirillo, J.D., Falkow, S., and Tompkins, L.S., 1994, Growth of Legionella pneumophila in Acanthamoeba castellani enhances invasion, Infect. Immun. 62: 3254–3261.
Damsker, B., and Bottone, E.J., 1985, Mycobacterium avium-Mycobacterium intracellulare from the intestinal tracts of patients with the acquired immunodeficiency syndrome: concepts regarding acquisition and pathogenesis, J. Infect. Dis. 151: 179–180.
Falkinham III, J.O., 1996, Epidemiology of infection by nontuberculous mycobacteria, Clin. Microbiol. Rev. 9: 177–215.
Finlay, B.B., and Ruschkowski, S., 1991, Cytoskeletal rearrangements accompanying Salmonella entry into epithelial cells, J. Cell Sci. 99: 283–296.
Fujimura, Y., 1986, Functional morphology of microfold cells (M cells) in Peyer’s Patchesphagocytosis and transport of BCG by M cells in rabbit Peyer’s Patches, Gastroenterol. Jap. 21: 325–330.
Glover, N., Holzman, A., Aronson, T., Proman, B., Berlin, G.W., Dominguez, P., Konzel, K.A., Overturf, G., Stelma, G., Smith, C., and Yakrus, M., 1994, The isolation and identification of Mycobacterium avium complex recovered from Los Angeles potable water, a possible source of infection in AIDS patients, Int. J. Environ. Health Res. 4: 63–72.
Hedges, S.R., Agace, W.W., and Svanborg, C.,1995, Epithelial cytokine responses and mucosal cytokine networks, Trends Microbiol. 3: 266–270.
Horsburgh Jr, C.R., 1991, Mycobacterium avium complex in the acquired immunodeficiency syndrome (AIDS), N. Engl. J. Med. 324: 1332–1338.
Hsu, N., Goodman, J.R., Young, L.S., and Bermudez, L.E., 1996, Interaction between Mycobacterium avium complex and intestinal mucosal cells in vivo, in: 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Abstract #B25.
Huang, J., O’Toole, P.W., Doig, P., and Trust, 11,1995, Stimulation of interleukin-8 production in epithelial cell lines by Helicobacter pylori, Infect. Immun. 63: 1732–1738.
Hueck, C.J., 1998, Type III protein secretion systems in bacterial pathogens of animals and plants, Microbiol. Mol. Biol. Rev. 62: 379–433.
Inderlied, C.B., Kemper, C.A., and Bermudez, L.E., 1993, The Mycobacterium avium complex, Clin. Microbiol. Rev. 6: 266–310.
Jacobson, M.A., Hopewell, P.C., Yajko, D.M., Hadley, W.K., Lazarus, E., Mohanty, P.K., Modin, G.W., Feigal, D.W., Cusick, P.S., and Sande, M.A., 1991, Natural history of disseminated Mycobacterium avium complex infection in AIDS, J. Infect. Dis. 164: 994–998.
Jepson, M.A., and Clark, M.A., 1998, Studying M cells and their role in infection, Trends Microbiol. 6: 359–365.
Jones, B.D., Ghori, N., and Falkow, S., 1994, Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer’s Patches, J. Exp. Med. 180: 15–23.
Jung, H.C., Eckmann, L., Yang, S.K., Panja, A., Fierer, J., Wroblewska, E., and Kagnoff, M.F., 1995, A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in respone to bacterial invasion, J. Clin. Invest. 95: 55–65.
Kim, S.Y., Goodman, J.R., Petrofsky, M., and Bermudez, L.E., 1998, Mycobacterium avium infection of the gut mucosa in mice is associated with later inflammatory response and ultimately results in areas of intestinal cell necrosis, J. Med. Microbiol. 47: 725–731.
Laurent, F., Eckmann, L., Savidge, T.C., Morgan, G., Theodos, C., Naciri, M., and Kagnoff, M.F., 1997, Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines, Infect. Immun. 65: 5067–5073.
Lee, C.A., 1977, Type III secretion systems: machines to deliver bacterial proteins into eukaryotic cells? Trends Microbiol. 5: 148–156.
Lin, Y., Zhang, M., and Barnes, P., 1998, Chemokine production by a human alveolar epithe- lial cell line in response to Mycobacterium tuberculosis, Infect. Immun. 66: 1121–1126.
Mazurek, G.H., Chin, D.P., Hartman, S., Reddy, V., Horsburgh Jr., R.C., Green, T.A., Yajko, D.M., Hopewell, P.C., Reingold, A.L., and Crawford, J.T., 1997, Genetic similarity among Mycobacterium avium isolates from blood, stool and sputum of persons with AIDS, J. Infect. Dis. 176: 976–983.
McDonough, K., and Kress, Y., 1995, Cytotoxicity for lung epithelial cells is a virulence-associated phenotype of Mycobacterium tuberculosis, Infect. Immun. 63: 4802–4811.
McDonough, K.A., Kress, Y., and Bloom, B.R., 1993, Pathogenesis of tuberculosis: Interaction with macrophages, Infect. Immun. 61: 2763–2773.
Mehta, P.K., King, C.H., White, E.H., Murtagh Jr., J.J., and Quinn, R.D., 1996, Comparison of in vitro models for the study of Mycobacterium tuberculosis invasion and intracellular replication, Infect. Immun. 64: 2673–2679.
Neutra, M.R., Frey, A., and Kraehenhuhl, J.P., 1996, Epithelial M Cells: Gatesways for mucosal infection, Cell 86: 345–348.
Oelschlaeger, T.A., Guerry, P., and Kopecko, D.1,1993, Unusual microtubule-dependent endocytosis mechanisms triggered by Campylobacter jejuni and Citrobacter freundii, Proc. NatL Acad. Sci. USA 90: 6884–6888.
Pepe, J.C., Wachtel, M.R., Wager, E., and Miller, V.L., 1995, Pathogenesis of the defined invasion mutants of Yersinia enterocolitica in a BALB/C mouse model of infection, Infect. Immun. 63: 4837–4848.
Rasmussen, S.J., Eckmann, L., Quayle, A.J., Shen, L., Zhang, Y.X., Anderson, D.J., Fierer, J., Stephens, R.S., and Kagnoff, M.F., 1997, Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis, J. Clin. Invest. 99: 77–87.
Rosenshine, I., Donnenberg, M.S., Karper, J.B., and Finlay, B.B., 1992, Signal transduction between enteropathogenic Escheria coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake, EMBO J. 11 :3551–3560.
Schorey, J.F., Li, Q., McCourt, D., Bong-Mastek, M., Clark-Curtiss, J., Ratliff, T.L., and Brown, E.J., 1996a, A Mycobacterium leprae gene encoding a fibronectin binding protein is used for efficient invasion of epithelial cells and Schwann cells, Infect. Immun. 63: 2652–2657.
Schorey, J.S., Holsti, M.D., Ratliff, T.L., Allen, P.M., and Brown, E.J., 1996b, Characterization of fibronectin-attachment protein of Mycobacterium avium reveals a fibronectin-binding motif conserved among mycobacteria, Mol. Microbiol. 21: 321–330.
Segal, E.D., Falkow, S., and Tompkins, L.S., 1996, Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphoylation of host cell proteins, Proc. Natl. Acad. Sci. USA 93: 1259–1264.
Shepard, C.C., 1957, Growth characteristics of tubercle bacilli and certain other mycobacteria in HeLa cells, J. Exp. Med. 105: 39–48.
Sturgill-Koszycki, S., Schlesinger, P.H., Chakraborty, P., Haddix, P.L., Collins, H.L., Fok, A.K., Allen, R.D., Gluck, S.L., Heuser, J., and Russell, D.G., 1994, Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase, Science 263: 678–681.
Tan, T., Sangari, F., Petrofsky, M., and Bermudez, L., 1998, M. avium secretes proteins upon contact with intestinal cells in vitro,Submitted.
Torriani, E, Maslow, J.N., Kornbluth, R., Arbeit, R.D., McCutchan, J.A., Hasegawa, P., Keays, L., and Havlir, D., 1995, Analysis of Mycobacterium avium complex isolates infecting multiple organs of AIDS patients using pulsed field gel eletrophoresis, in: Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, American Society for Microbiology. Abstract #I-91.
Walker, D.H., Firth, W.T., Ballard, J.G., and Hegarty, B.C., 1983, Role of phospholipaseassociated penetration mechanism in cell injury by Rickettsia rickettsii, Infect. Immun. 40: 840–842.
Zhang, M., Kim, K.J., Iyer, D., Lin, Y., Belisle, J., McEnery, K., Crandall, E.D., and Barnes, P.F., 1997, Effects of Mycobacterium tuberculosis on the bioelectric properties of the alveolar epithelium, Infect. Immun. 65: 692–698.
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Bermudez, L.E., Sangari, F.J. (2000). Mycobacterial Invasion of Epithelial Cells. In: Oelschlaeger, T.A., Hacker, J. (eds) Bacterial Invasion into Eukaryotic Cells. Subcellular Biochemistry, vol 33. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4580-1_10
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DOI: https://doi.org/10.1007/978-1-4757-4580-1_10
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