Abstract
Lymphedema can be defined as a clinical presentation characterized by an excessive regional interstitial accumulation of protein-rich fluid. This common clinical disorder most typically arises when regional microcirculatory imbalances are created by a loss of lymphatic transport capacity. Whenever the lymphatic circulation is damaged, diseased, or malformed, a spectrum of derangements can result.
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References
Szuba A, Rockson S: Lymphedema: anatomy, physiology and pathogenesis. Vasc Med 1997, 2: 321–326.
Rockson SG: Lymphedema. Am J Med 2001, 110: 288295.
Rockson SG: Primary lymphedema. In Current Therapy in Vascular Surgery, edn 4. Edited by Ernst CB, Stanley JC. Philadelphia: Mosby; 2000: 915–918.
Dumont DJ, Jussila L, Taipale J, et al.: Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 1998, 282:946–949.
Velanovich V, Szymanski W: Quality of life of breast cancer patients with lymphedema. Am J Surg 1999, 177 (3): 184–187.
Brautigam P, Foldi E, Schaiper I, et al.: Analysis of lymphatic drainage in various forms of leg edema using two compartment lymphoscintigraphy. Lymphology 1998, 31:43–55.
Mostbeck A, Partsch H: Isotope lymphography-possibilities and limits in evaluation of lymph transport [in German]. Wien Med Wochenschr 1999, 149: 87–91.
Kinmonth JB, Taylor GW, Tracy GD, Marsh JD: Primary lymphoedema. Clinical and lymphangiographic studies of a series of 107 patients in which the lower limbs were affected. Br J Surg 1957, 45: 1–10.
Starling EH: On the absorption of fluids from the connective tissue spaces. J Physiol 1896, 19: 312.
Landis EM, Pappenheimer JR: Exchange of substances through capillary walls. In Handbook of Physiology, Section 2, Circulation, vol II. Edited by Hamilton WF, Dow P. Washington, DC: American Physiological Society; 1963: 961–1034.
Guyton AC, Grangher HJ, Taylor AE: Interstitial fluid pressure. Physiol Rev 1971, 51: 527–563.
Wolfe IHN, Kinmonth JB: The prognosis of primary lymphedema of the lower limbs. Arch Surg 1981, 116: 1157–1160.
Karkkainen MJ, Ferrell RE, Lawrence EC, et al.: Missense mutations interfere with VEGF-3 signalling in primary lymphoedema. Nat Genet 2000, 25:153–159.
Mangion J, Rahman N, Mansour S, et al.: A gene for lymphedemadistichiasis maps to 16q24.3. Am J Hum Genet 1999, 65:427–432.
Segerstrom K, Bjerle P, Graffman S, Nystrom A: Factors that influence the incidence of brachial oedema after treatment of breast cancer. Scand J Plast Reconstr Surg Hand Surg 1992, 26 (2): 223–227.
Svensson WE, Mortimer PS, Tohno E, Cosgrove DO: Colour Doppler demonstrates venous flow abnormalities in breast cancer patients with chronic arm swelling. Eur J Cancer 1994, 30A: 657–660.
Rockson SG: Precipitating factors in lymphedema: myths and realities. Cancer 1998, 83: 2814–2816.
Ward LC, Bunce IH, Cornish BH, et al.: Multi-frequency bioelectrical impedance augments the diagnosis and management of lymphoedema in post-mastectomy patients. Eur J Clin Invest 1992, 22:751–754.
Vaughan BF: CT of swollen legs. Clin Radiol 1990, 41: 24–30.
O’Donnell TF, Edwards JM, Kinmonth JB: Lymphography in congenital mixed vascular deformities of the lower extremities. J Cardiovasc Surg 1976, 17: 535–540.
Stewart G, Gaunt JI, Croft DN, Browse NL: Isotope lymphography: a new method of investigating the role of the lymphatics in chronic limb oedema. Br J Surg 1985, 72: 906–909.
Ter SE, Alavi A, Kim CK, Merli G: Lymphoscintigraphy: a reliable test for the diagnosis of lymphedema. Clin Nucl Med 1993, 18: 646–654.
Gloviczki P, Calcagno D, Schirger A, et al.: Noninvasive evaluation of the swollen extremity: experiences with 190 lymphoscintiographic examinations. J Vasc Surg 1989, 9:683–690.
Rockson SG, Miller LT, Seine R, et al.: American Cancer Society Lymphedema Workshop. Workgroup III: Diagnosis and management of lymphedema. Cancer 1998, 83:2882–2885.
Szuba A, Cooke JP, Yousuf S, Rockson SG: Decongestive lymphatic therapy for patients with cancer-related or primary lymphedema. Am J Med 2000, 109: 296–300.
Charles RH: A System of Treatment, vol 3. Edited by Latham A, English TC. London: J A Churchill Ltd; 1912: 504.
Brorson H, Svensson H: Liposuction combined with controlled compression therapy reduces arm lymphedema more effectively than controlled compression therapy alone. Plast Reconstr Surg 1998, 102: 1058–1067.
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Rockson, S. (2003). Lymphatic Disease. In: Creager, M.A. (eds) Atlas of Vascular Disease. Current Medicine Group, London. https://doi.org/10.1007/978-1-4757-4564-1_12
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DOI: https://doi.org/10.1007/978-1-4757-4564-1_12
Publisher Name: Current Medicine Group, London
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