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Epidemiology of Osteoporosis and Associated Fractures

  • Loran M. Salamone

Abstract

Osteoporosis is a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk [1]. Osteoporosis is the most prevalent metabolic bone disease in the United States and in other developed countries. In the United States, as many as 54% (16.8 million) of postmenopausal white women have low bone mass or osteopenia and another 30% (9.4 million) have osteoporosis. Among 50-year-old white women and men, the estimated lifetime fracture risk is 40% in women and 13% in men [2].

Keywords

Bone Mineral Density Bone Density White Woman Osteoporotic Fracture Wrist Fracture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Consensus Development Conference: Diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 1993, 94:646–650.CrossRefGoogle Scholar
  2. 2.
    Melton LJ III, Chrischilles EA, Cooper C, et al.: Perspective: How many women have osteoporosis? J Bone Miner Res 1992, 7:1005–1010.PubMedCrossRefGoogle Scholar
  3. 3.
    Melton LJ III: How many women have osteoporosis now? J Bone Miner Res 1995, 10:175–177.PubMedCrossRefGoogle Scholar
  4. 4.
    Jones G, Nguyen T, Sambrook PN, et al.: Symptomatic fracture incidence in elderly men and women: the Dubbo Osteoporosis Epidemiology Study. Osteoporosis Int 1994, 4:277–282CrossRefGoogle Scholar
  5. 5.
    Center J, Eisman J: The epidemiology and prevention of osteoporosis. Bailliere’s Clin Endocrinol Metab 1997, 11:23–62.CrossRefGoogle Scholar
  6. 6.
    Nguyen T, Sambrook P, Kelly P, et al: Prediction of osteoporotic fractures by postural instability and bone density. BMJ 1993, 307:1111–1115.PubMedCrossRefGoogle Scholar
  7. 7.
    Miller PD, Bonnick SL, Rosen CJ: Consensus of an international panel on the clinical utility of bone mass measurements in the detection of low bone mass in the adult population. Calcif Tiss Int 1996, 58:207–214.Google Scholar
  8. 8.
    Cooper C, Melton U III: Magnitude and impact of osteoporosis and fractures. In Osteoporosis. Edited by Marcus R. San Diego: Academic Press. 1996:419–34.Google Scholar
  9. 9.
    Seeley DG, Browner WS, Nevitt MC, et al., and the Study of Osteoporotic Fractures Group: Which fractures are associated with low appendicular bone mass in elderly women. Ann Intern Med 1991, 115:837–842.PubMedCrossRefGoogle Scholar
  10. 10.
    Kanis JA, Melton LJ III, Christiansen C, et al.: The diagnosis of osteoporosis. J Bone Miner Res 1994, 9:1137–1141.PubMedCrossRefGoogle Scholar
  11. 11.
    Wasnish RD: Epidemiology of osteoporosis. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, edn 3. Edited by Favus MJ. Philadelphia: Lippincott-Raven, 1996:249–251.Google Scholar
  12. 12.
    Ralston SH: Genetic control of susceptibility to osteoporosis. J Clin Endocrinol Metab 2002, 87:2460–2466.PubMedCrossRefGoogle Scholar
  13. 13.
    Looker AC, Orwoll ES, Johnston CC Jr, et al.: Prevalence of low femoral bone density in older U.S. adults from NHANES III. J Bone Miner Res 1997, 12:1761–1768.PubMedCrossRefGoogle Scholar
  14. 14.
    Looker AC, Johnston CC Jr, Wahner HW, et al.: Prevalence for low femoral bone density in older U.S. women from NHANES III. J Bone Miner Res 1995, 10:796–802.PubMedCrossRefGoogle Scholar
  15. 15.
    National Osteoporosis Foundation: 1996 and 2015 osteoporosis prevalence figures. State-by-state report. January 1997.Google Scholar
  16. 16.
    Cooper CC, Campion G, Melton LJ III: Hip fractures in the elderly: a worldwide projection. Osteoporosis Int 1992, 2:285–289.CrossRefGoogle Scholar
  17. 17.
    Gullberg B, Johnell O, Kanis JA: World-wide projections for hip fracture. Osteoporosis Int 1997, 7:407–413.CrossRefGoogle Scholar
  18. 18.
    Cummings SR, Black DM, Nevitt MC, et al.: Bone density at various sites for the prediction of hip fractures. Lancet 1993, 341:72–75.PubMedCrossRefGoogle Scholar
  19. 19.
    Cooper C, Melton LJ III: Epidemiology of osteoporosis. Trends Endocrinol Metab 1992, 3:224–229.PubMedCrossRefGoogle Scholar
  20. 20.
    Ensrud KE, Lipschutz RC, Cauley JA, et al.: Body size and hip fracture risk in older women: a prospective study. Study of Osteoporotic Research Group. Am J Med 1997, 103:274–280.PubMedCrossRefGoogle Scholar
  21. 21.
    Leske MC, Ederer F, Podgor M: Estimating incidence from age-specific prevalence in glaucoma. Am J Epidemiol 1981, 113:606–613.PubMedGoogle Scholar
  22. 22.
    Melton LJ, Lane AW, Cooper C, et al.: Prevalence and incidence of vertebral deformities. Osteoporosis Int 1993, 3:113–119.CrossRefGoogle Scholar
  23. 23.
    Incidence of vertebral fracture in Europe: Results from the European Prospective Osteoporosis Study (EPOS). J Bone Miner Res 2002, 17:716–724.CrossRefGoogle Scholar
  24. 24.
    Kanis JA, McCloskey EV: Evaluation of the risk of hip fracture. Bone 1996, 18:127S–132S.CrossRefGoogle Scholar
  25. 25.
    Cummings SR, Nevitt MC, Browner WS, et al.: Risk factors for hip fracture in white women. N Engl J Med 1995, 332:767–773.PubMedCrossRefGoogle Scholar
  26. 26.
    Nguyen TV, Elsman JA, Kelly PJ, Sambrook PN: Risk factors for osteoporotic fractures in elderly men. Am J Epidemiol 1996, 144:255–263.PubMedCrossRefGoogle Scholar
  27. 27.
    Grisso JA, Kelsey JL, Strom BL, et al.: Risk factors for hip fracture in black women. N Engl J Med 1994, 330:1555–1559.PubMedCrossRefGoogle Scholar
  28. 28.
    Melton LJ III, Thamer M, Ray NF, et al.: Fractures attributable to osteoporosis: report from the National Osteoporosis Foundation. J Bone Miner Res 1997, 12:16–23.PubMedCrossRefGoogle Scholar
  29. 29.
    Nevitt MC, Cummings SR, and the Study of Osteoporotic Fractures Research Group: Type of fall and risk of hip and wrist fractures: The Study of Osteoporotic Fractures. J Am Geriatr Soc 1993, 41:1226–1234.PubMedGoogle Scholar
  30. 30.
    Nguyen TV, Center JR, Sambrook PN, Eisman JA: Risk factors for proximal humerus, forearm, and wrist fractures in elderly men and women. The Dubbo Osteoporosis Epidemiology Study. Am J Epidemiol 2001, 153:587–595.PubMedCrossRefGoogle Scholar
  31. 31.
    Center JR, Nguyen TV, Schneider DS, et al.: Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 1999, 353: 878–882.PubMedCrossRefGoogle Scholar
  32. 32.
    Ray NF, Chan J, Thamer M, Melton JL III: Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: Report from the National Osteoporosis Foundation. J Bone Miner Res 1997, 12:24–35.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 2003

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  • Loran M. Salamone

There are no affiliations available

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