Abstract
The field of neuro-oncology is a relatively young one. Most of the advances in neurologic diagnosis and therapy relevant to neuro-oncology have occurred within the last 85 years. Before the development of theories of neurologic localization, the presence of a brain tumor could be suspected, but treatment was impossible. Once preoperative localization using clinical examination techniques was possible, surgery for diagnosis and treatment of brain tumors was an option, but successful brain tumor surgery required the development of aseptic surgical techniques, anesthetics, antibiotics, and corticosteroids. Nonsurgical treatments for brain tumors were also developed in the twentieth century, including radiotherapy and chemotherapy. Refinements of these treatments are still being developed, and include γ-knife radiosurgery, radiosensitizers, localized chemotherapy using polymer wafers, gene therapy, and multiagent chemotherapy regimens for specific brain tumors.
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References
Giles GG, Gonzales MF: Epidemiology of Brain Tumors and Factors in Prognosis. In Brain Tumors: An Encyclopedic Approach. Edited by Kaye AH, Laws ER Jr. New York: Churchill Livingstone; 1994: 47–67.
Whelan SL, Parkin DM, Masuyer E: Patterns of Cancer in Five Continents. Edited by Whelan SL, Parkin DM, Masuyer E. Lyon: International Agency for Research on Cancer; 1990. [IARC Scientific Publications, vol 102.]
Bahemuka M: Worldwide incidence of primary nervous system neoplasms. Geographical, racial and sex differences, 1960–1977. Brain 1988, 111: 737–755.
Velema JP, Walker AM: The age curve of nervous system tumor incidence in adults: common shape but changing levels by sex, race and geographical location. Int J Epidemiol 1987, 16: 177–183.
Schoenberg BS, Christine BW, Whisnant JP: The resolution of discrepancies in the reported incidence of primary brain tumors. Neurology 1978, 28: 817–823.
Annegers JF, Schoenberg BS, Okazaki H, et al.: Epidemiologic study of primary intracranial neoplasms. Arch Neurol 1981, 38:217–219.
Kurland LT, Schoenberg BS, Annegers JF, et al.: The incidence of primary intracranial neoplasms in Rochester, Minnesota, 1935–1977. Ann NYAcad Sci 1982, 381:6–16.
Walker AE, Robins M, Weinfeld FD: Epidemiology of brain tumors: the national survey of intracranial neoplasms. Neurology 1985, 35: 219–226.
Cairncross JG, Posner JB: The management of brain metastases. In Oncology of the Nervous System. Edited by Walker MD. Boston: Martinus Nijhoff; 1983: 341–377.
Delattre JY, Krol G, Thaler HT, et al.: Distribution of brain metastases. Arch Neurol 1988, 45:741–744.
Evans RG: The role of radiation therapy in the treatment of brain tumors in children. In Brain Tumors: A Comprehensive Text. Edited by Morantz RA, Walsh JW. New York: Marcel Dekker; 1994: 659–677.
Levin VA, Sheline GE, Gutin PH: Neoplasms of the Central Nervous System. In Cancer: Principles and Practice of Oncology, vol 2. Edited by DeVita VT Jr, Hellman S, Rosenberg SA. Philadelphia: JB Lippincott; 1989: 1557–1611.
Daumas-Duport C, Scheithauer BW, O’Fallon JR, et al.: Grading of astrocytomas: a simple and reproducible method. Cancer 1988, 62:2152–2165.
Shaw EG, Daumas-Duport C, Scheithauer BW, et al.: Radiation therapy in the treatment of low-grade supratentorial astrocytomas. J Neurosurg 1989, 70:853–861.
Guthrie BL, Laws ER Jr: Supratentorial low-grade gliomas. Neurosurg Clin North Am 1990, 1: 37–48.
Devaux BC, O’Fallon JR, Kelly PJ: Resection, biopsy, and survival in malignant glial neoplasms. J Neurosurg 1993, 78: 767–775.
Laws ER Jr, Taylor WF, Clifton MB, et al.: Neurosurgical management of low-grade astrocytoma of the cerebral hemisphere. J Neurosurg 1984, 61:665–673.
Burger PC, Vogel FS, Green SB, et al.: Glioblastoma multiforme and anaplastic astrocytoma: pathologic criteria and prognostic implications. Cancer 1985, 56:1106–1111.
Burger PG, Green SB: Patient age, histologic features, and length of survival in patients with glioblastoma multiforme. Cancer 1987, 59: 1617–1625.
Salcman M: Malignant glioma management. Neurosurg Clin North Am 1990, 1: 49–61.
Curran WJ Jr, Scott CB, Horton J, et al.: Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst 1993, 85:704–710.
Schold SC Jr.: Unpublished data.
Pell MF, Thomas DGT: General Introduction to the Clinical Features of Malignant Brain Tumours. In Malignant Brain Tumours. Edited by Thomas DGT, Graham DI. London: Springer-Verlag; 1995: 109–114.
McKeran RO, Thomas DGT: The clinical study of gliomas. In Brain Tumours: Scientific Basis, Clinical Investigation and Current Therapy. Edited by Thomas DGT, Graham DI. London: Butterworth; 1980: 194–230.
Cascino GD: Epilepsy and brain tumours: implications for treatment. Epilepsia 1990, 31: 537–544.
Henry C, Despland PA, Regli F: Initial epileptic crisis after the age of 60: aetiology, clinical aspect and EEG. Schweiz Med Wochenschr 1990, 120: 787–792.
Salcman M, Kaplan RS: Intracranial Tumors in Adults. In Comprehensive Textbook of Oncology. Edited by Moosa AR, Bobson MD, Schimpff SD. Baltimore: Williams & Wilkins; 1986: 617–629.
Black P, Wen PY: Clinical, Imaging and Laboratory Diagnosis of Brain Tumors. In Brain Tumors: An Encyclopedic Approach. Edited by Kaye AH, Laws ER Jr. Hong Kong: Churchill Livingstone; 1995: 191–214.
Kraemer DL, Bullard DE: Clinical Presentation of the Brain Tumor Patient. In Brain Tumors: A Comprehensive Text. Edited by Morantz RA, Walsh JW. New York: Marcel Dekker; 1994: 183–211.
Balhuizen JC, Bots GT, Schaberg A, et al.: The incidence of multifocal cerebral gliomas: a histologic study of large hemisphere sections. Cancer 1987, 60:1519–1531.
Bigner SH, Johnston WW: The diagnostic challenge of tumors manifested initially by the shedding of cells into cerebrospinal fluid. Acta Cytol 1984, 28: 29–36.
Choucair AK, Leven VA, Gutin PH, et al.: Development of multiple lesions during radiation therapy and chemotherapy in patients with gliomas. J Neurosurg 1986, 65:654–658.
Segall HD, Destian S, Nelson Jr MD, et al.: CT and MR Imaging in Malignant Gliomas. In Malignant Cerebral Glioma. Edited by Apuzzo MLJ. Park Ridge, IL: American Association of Neurological Surgeons; 1991:63–78.
Kelly PJ, Daumas-Duport C, Kispert DB, et al.: Imaging-based stereotaxic serial biopsies in untreated intracranial glial neoplasms. J Neurosurg 1987, 66:865–874.
Fujii K, Fujita N, Hirabuki N, et al.: Neuromas and meningiomas: evaluation of early enhancement with dynamic MR imaging. AJNR 1992, 13:1215–1220.
Goldsher D, Litt AW, Pinto RS, et al.: Dural “tail” associated with meningiomas on Gd-DTPA-enhanced MR images: characteristics, differential diagnostic value, and possible implications of treatment. Radiology 1990, 176:447–450.
Tien RD, Yang PJ, Chu PK: “Dural tail sign”: A specific MR sign for meningioma? J Comput Assist Tomogr 1991, 15: 64–66.
Chen TC, Zee CS, Miller CA, et al.: Magnetic resonance imaging and pathological correlates of meningiomas. Neurosurgery 1992, 31:1015–1022.
Constantini S, Tamir J, Gomori MJ, et al.: Tumor prostaglandin levels correlate with edema around supratentorial meningiomas. Neurosurgery 1993, 33:204–211.
Jaaskelainen J: Seemingly complete removal of histologically benign intracranial meningioma: late recurrence rate and factors predicting recurrence in 657 patients. Surg Neurol 1986, 25: 461–469.
Jaaskelainen J, Haltia M, Servo A: Atypical and anaplastic meningiomas: radiology, surgery, radiotherapy and outcome. Surg Neurol 1986, 25: 233–242.
DeMonte F, Al-Mefty O: Meningiomas. In Brain Tumors: An Encyclopedic Approach. Edited by Kaye AH, Laws ER Jr. Hong Kong: Churchill Livingstone; 1995: 675–704.
Ho VB, Smirniotopoulos JG, Murphy FM, et al.: Radiologie-pathologic correlation: hemangioblastoma. AJNR 1992, 13:1343–1352.
Lee Y-Y, Van Tassel P, Bruner JM, et al.: Juvenile pilocytic astrocytomas: CT and MR characteristics. AJNR 1989, 10:363–370.
Neumann HPH, Eggert HR, Scheremet R, et al.: Central nervous system lesions in von Hippel-Lindau syndrome. J Neurol Neurosurg Psychiatry 1992, 55:898–901.
Leibel SA, Sheline GE: Radiation therapy for neoplasms of the brain. J Neurosurg 1987, 66: 1–22.
DiChiro G, Hatazawa J, Katz DA, et al.: Diagnostic and Prognostic Value of Positron Emission Tomography Using [18F]-Fluorodeoxyglucose in Brain Tumors. In Positron Emission Tomography. Edited by Reivich M, Alavi A. New York: Alan R Liss; 1985:291–309.
Alavi JB, Alavi A, Chawluk J, et al.: Positron emission tomography in patients with gliomas. A predictor of prognosis. Cancer 1988, 62:1074–1078.
Valk PE, Budinger TF, Levin VA, et al.: PET of malignant cerebral tumors after interstitial brachytherapy. Demonstration of metabolic activity and correlation with clinical outcome. J Neurosurg 1988, 69:830–838.
Le Bihan D, Douek M, Argyropoulou M, et al.: Diffusion and perfusion magnetic resonance imaging in brain tumors. Top Magnetic Resonance Imaging 1993, 5:25–31.
Scharfen CO, Sneed PK, Wara WM, et al.: High activity iodine-125 interstitial implant for gliomas. Int J Radiat Oncol Biol Phys 1992, 24:583–591.
Salcman M: Intracranial hemorrhage caused by brain tumor. In Intracerebral Hematomas. Edited by Kaufman HH. New York: Raven Press; 1992: 95–106.
Kleihues P, Burger PC, Scheithauer BW: The new WHO classification of brain tumors. Brain Pathol 1993, 3: 255–268.
Kleihues P, Burger PC, Scheithauer BW: Histological Typing of Tumours of the Central Nervous System, edn 2. Berlin: Springer-Verlag; 1993.
Ringertz N: Grading of gliomas. Acta Pathol Microbiol Scand 1950, 27: 51–64.
Svien HJ, Mabon RF, Kernohan JW, et al.: Astrocytomas. Proc Staff Meet Mayo Clin 1949, 24:54–63.
Burger PC, Vollmer RT: Histological factors of prognostic significance in glioblastoma multiforme. Cancer 1980, 46: 1179–1186.
Daumas-Duport C, Scheithauer B, O’Fallon J, et al.: Grading of astrocytomas. A simple and reproducible method. Cancer 1988, 62:2152–2165.
Nelson JS, Tsukada Y, Schoenfeld D: Necrosis as a prognostic criterion in malignant, supratentorial astrocytic gliomas. Cancer 1983, 52: 550–554.
Coons SW, Johnson P: Histopathology of astrocytomas: grading, patterns of spread and correlation with modern imaging modalities. Semin Radiat Oncol 1991, 1: 2–9.
Berger PC, Scheithauer BW: Atlas of Tumor Pathology: Tumors of the Central Nervous System. Washington, DC: Armed Forces Institute of Pathology; 1994. [Third series; fascicle 10.]
Russell DS, Rubinstein LJ: Pathology of Tumors of the Nervous System, edn 5. Baltimore: Williams & Wilkins; 1989.
Albright AL, Packer RJ, Zimmerman R, et al.: Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: a report from Children’s Cancer Group. Neurosurgery 1993, 33:1026–1029.
Hoffman HJ, Soloniuk DS, Humphreys RP, et al.: Management and outcome of low-grade astrocytomas of the midline in children: a retrospective review. Neurosurgery 1993, 33:964–971.
Macdonald D: Low grade gliomas, mixed gliomas and oligodendrogliomas. Semin Oncol 1994, 21: 236–248.
Sutton LN, Molloy PT, Sernyak H, et al.: Long-term outcome of hypothalamic/chiasmatic astrocytomas in children treated with conservative surgery. J Neurosurg 1995, 83:583–589.
Rushing EJ, Rorke LB, Sutton L: Problems in the nosology of desmoplastic tumors of childhood. Pediatr Neurosurg 1993, 19: 57–62.
Vandenberg SR: Current diagnostic concepts of astrocytic tumors. J Neuropathol Exp Neurol 1992, 51: 644–657.
Chen TC, Gonzalez-Gomez I, McComb JG: Uncommon Glial Tumors. In Brain Tumors. Edited by Kaye AH, Laws ER Jr. New York: Churchill Livingstone; 1995: 525–557.
Hirose T, Scheithauer BW, Lopes MBS, et al.: Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: an immunohistochemical, ultra-structural, and immunoelectron microscopic study. Acta Neuropathol 1995, 90:387–399.
Nixon JR, Miller GM, Okazaki H, et al.: Cerebral tuberous sclerosis: postmortem magnetic resonance imaging and pathologic anatomy. Mayo Clin Proc 1989, 64:305–311.
Cairncross G, Macdonald D, Ludwin S, et al.: Chemotherapy for anaplastic oligodendroglioma: National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 1994, 12:2013–2021.
Lombardi D, Scheithauer BW, Meyer FB, et al.: Symptomatic subependymoma: a clinicopathologic and flow cytometric study. J Neurosurg 1991, 75:583–588.
Ho DM, Wong TT, Liu HC: Choroid plexus tumors in childhood: histopathologic study and clinicopathological correlation. Childs Nery Sys 1991, 7: 437–441.
Mena H, Rushing EJ, Ribas JL, et al.: Tumors of pineal parenchymal cells: a correlation of histological features, including nucleolar organizer regions, with survival in 35 cases. Hum Pathol 1995, 26:20–30.
Sure U, Bertalanffy H, Isenmann St, et al.: Secondary manifestations of medulloblastoma: metastases and local recurrences in 66 patients. Acta Neurochir (Wien) 1995, 136:117–126.
National Institutes of Health Consensus Development Conference statement on acoustic neuroma. December 11–13, 1991. Arch Neurol 1994, 51: 201–207.
Ng H, Lau K, Tse JYM, et al.: Combined molecular genetic studies of chromosome 22q and the neurofibromatosis type 2 gene in central nervous system tumors. Neurosurgery 1995, 37:764–773.
Sobel RA, Wang Y: Vestibular (acoustic) schwannomas: histologic features in neurofibromatosis 2 and unilateral cases. J Neuropathol Exp Neural 1993, 52: 106–113.
Roach, ES: Diagnosis and management of neurocutaneous syndromes. Semin Neurol 1988, 8: 83–96.
Newman S: Meningiomas: a quest for the optimum therapy. J Neurosurg 1994, 80: 191–194.
Sherman ME, Erozan YS, Mann RB, et al.: Stereotactic brain biopsy in the diagnosis of malignant lymphoma. Am J Clin Pathol 1991, 95:878–883.
Miller DC: Histopathologic Evaluation of Pituitary Tumors: Help for the Clinician. In: Contemporary Diagnosis and Management of Pituitary Adenomas. Edited by Cooper PR. Park Ridge, IL: American Association of Neurological Surgeons; 1991: 37–45.
Brada M, Thomas DGT: Craniopharyngioma revisited. Int J Radiat Oncol Biol Phys 1993, 27: 471–475.
Earnest F IV, Kelly PJ, Scheithauer BW, et al.: Cerebral astrocytomas: histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy. Radiology 1988, 166:823–827.
Devaux BC, O’Fallow JR, Kelly PJ: Resection, biopsy, and survival in malignant glial neoplasms. J Neurosurg 1993, 78: 767–775.
Walker MD, Alexander E Jr, Hunt WE, et al.: Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas-a cooperative clinical trial. J Neurosurg 1978, 49:333–343.
Schultheiss TE, Stephens LC, Jiang GL, et al.: Radiation myelopathy in primates treated with conventional fractionation. Int J Radiat Oncol Biol Phys 1990, 19:935–940.
Duffner PK, Cohen ME, Thomas PRM, et al.: The long-term effects of cranial irradiation on the central nervous system. Cancer 1985, 56:1841–1846.
Packer RJ, Sutton LN, Atkins TE, et al.: A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results. J Neurosurg 1987, 70:707–713.
Cohen ME, Duffner PK: Long-term clinical effects. In Brain Tumors in Children: Principles of Diagnosis and Treatment. Edited by Cohen ME, Duffner PK. New York: Raven Press; 1994: 455–481.
Twijnstra A, Boon PJ, Lormans ACM, et al.: Neurotoxicity of prophylactic cranial irradiation in patients with small cell carcinoma of the lung. Eur J Cancer Clin Oncol 1987, 23:983–986.
Hochberg FH, Slotnick B: Neuropsychologic impairment in astrocytoma survivors. Neurology 1980, 30: 172–177.
Shalet SM: Irradiation induced growth failure. Clin Endocrinol Metab 1986, 15: 591–606.
Constine LS, Woolf PD, Cann D, et al.: Hypothalamic-pituitary dysfunction after radiation for brain tumors. N Engl J Med 1993, 328:87–94.
Valk PE, Budinger TF, Levin VA, et al.: PET of malignant cerebral tumors after interstitial brachytherapy. Demonstration of metabolic activity and correlation with clinical outcome. J Neurosurg 1988, 69:830–838.
Glantz MJ, Burger PC, Friedman AH, et al.: Treatment of radiation-induced nervous system injury with heparin and warfarin. Neurology 1994, 44:2020–2027.
Valk PE, Dillon WP: Radiation injury of the brain. AJNR 1991, 12: 45–62.
Soffer D, Gomori JM, Siegal T, et al.: Intracranial meningiomas after high-dose irradiation. Cancer 1989, 63:1514–1519.
Dodick DW, Mokri B, Shaw EG, et al.: Sarcomas of calvarial bones: rare remote effect of radiation therapy for brain tumors. Neurology 1994, 44:908–912.
Green SB, Byar DP, Walker MD, et al.: Comparisons of carmustine, procarbazine and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma. Cancer Treat Rep 1983, 67:123–132.
Dropcho EJ, Rosenfeld SS, Morawetz RB, et al.: Pre-radiation intracarotid cisplatin treatment of newly diagnosed anaplastic gliomas. J Clin Oncol 1992, 10:452–458.
Salcman M, Kaplan RS, Samarns GM, et al.: Aggressive multimodality therapy based on a multicompartmental model of glioblastoma. Surgery 1982, 92:250–259.
Waliner KE, Galicich JH, Krol G, et al.: Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma. Int J Radiat Biol Oncol Phys 1989, 16:1405–1409.
Posner JB: Neurologic Complications of Cancer. Philadelphia: FA Davis; 1995. Contemporary Neurology Series, vol 45.
DeVita VT Jr, Hellman S, Rosenberg SA: Edpidemiology of Cancer. In Cancer Principles and Practice. Edited by DeVita VT Jr, Hellman S, Rosenberg SA. Philadelphia: JB Lippincott; 1993: 150–181.
Delattre JY, Krol G, Thaler HT, et al.: Distribution of brain metastases. Arch Neurol 1988, 45:741–744.
Cairncross JG, Kim J-H, Posner JB: Radiation therapy for brain metastases. Ann Neurol 1980, 7: 529–541.
Young DF, Posner JB, Chu F, et al.: Rapid-course radiation therapy of cerebral metastases: results and complications. Cancer 1974, 4:1069–1076.
Patchel RA, Tibbs PA, Walsh JW, et al.: A randomized trial of surgery in the treatment of single metastases to the brain. New Engl J Med 1990,322:494–500.
Bindal RK, Sawaya R, Leavens ME, et al.: Surgical treatment of multiple brain metastases. J Neurosurg 1993, 79:210–216.
Davis PC, Hudgins PA, Peterman SB, et al.: Diagnosis of cerebral metastases: double dose delayed CT vs contrast-enhanced MR imaging. AJNR 1991, 12:293–300.
Simpson RK Jr, Sirbasku DM, Baskin DS: Solitary brainstem metastasis: comparisons of x-ray computed tomography and magnetic resonance imaging to pathology. JNeuro-oncol 1987, 5: 57–63.
Yuh WTC, Engelken JD, Muhonen MG, et al.: Experience with high-dose gadolinium MR imaging in the evaluation of brain metastases. AJNR 1992, 13:335–354.
Fornasier VL, Horne JG: Metastases to the vertebral column. Cancer 1975, 36: 590–594.
Galasko CSB: The anatomy and pathways of skeletal metastases. In Bone Metastasis. Edited by Weiss L, Gilbert HA. Boston: GK Hall; 1981: 49–63.
Wong DA, Fornasier VL, MacNab I: Spinal metastases: the obvious, the occult and the imposters. Spine 1990, 15: 1–4.
Kamholtz R, Sze G: Current imaging in spinal metastatic disease. Semin Oncol 1991, 18: 744–746.
Helweg-Larsen S, Wagner A, Kjaer L, et al.: Comparison of myelography combined with post-myelographic spinal CT and MRI in suspected metastatic disease of the spinal canal. J Neuro-oncol 1992, 13:231–237.
Li KC, Poon PY: Sensitivity and specificity of MRI in detecting malignant spinal cord compression and in distinguishing malignant from benign compression fractures of vertebrae. Magn Reson Imaging 1988, 6: 547–556.
Smoker WR, Godersky JC, Knutzon RK, et al.: The role of MR imaging in evaluating metastatic spinal disease. AJR 1987, 149:1241–1248.
Greenberg HS, Kim J-H, Posner JB: Epidural spinal cord compression from metastatic tumor: results with a new treatment protocol. Ann Neural 1980, 8: 361–366.
Gasecki AP, Bashir RM, Foley J: Leptomeningeal carcinomatosis: a report of 3 cases and review of the literature. Eur Neurol 1992, 32: 74–78.
Wasserstrom W, Glass JP, Posner JB: Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer 1982, 49: 759–772.
Rosen ST, Aisner J, Makuch RW, et al.: Carcinomatous leptomeningitis in small cell lung cancer: a clinicopathologic review of the National Cancer Institute experience. Medicine 1982, 61:45–53.
Clouston PD, Saper CB, Arbizu T, et al.: Paraneoplastic cerebellar degeneration: III. Cerebellar degeneration, cancer and the Lambert-Eaton myasthenic syndrome. Neurology 1992, 42:1944–1950.
Peterson K, Rosenblum MK, Kotanides H, et al.: Paraneoplastic cerebellar degeneration: I. A clinical analysis of 55 anti-Yo antibody positive patients. Neurology 1992, 42:1931–1937.
Hammack J, Kotanides H, Rosenblum MK, et al.: Paraneoplastic cerebellar degeneration: II. Clinical and immunologic findings in 21 patients with Hodgkin’s disease. Neurology 1992, 42:1938–1943.
Furneaux HM, Rosenblum MK, Dalmau J, et al.: Selective expression of Purkinjecell antigens in tumor tissue from patients with paraneoplastic cerebellar degeneration. N Engl J Med 1990, 322:1844–1851.
Hetzel DJ, Stanhope CR, O’Neil BP, et al.: Gynecologic cancer in patients with subacute cerebellar degeneration predicted by anti-Purkinje cell antibodies and limited in metastatic volume. Mayo Clin Proc 1990, 65:1558–1563.
Hewett SJ, Atchison WD: Specificity of Lambert-Eaton myasthenic syndrome immunoglobulin for nerve terminal calcium channels. Brain Res 1992, 599: 324–332.
Leys K, Lang B, Johnston I, et al.: Calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome. Ann Neurol 1991, 29:307–314.
Cohen ME, Duffner PK: Medulloblastomas. In Brain Tumors in Children. Principles of Diagnosis and Treatment. Edited by Cohen ME, Duffner PK. New York: Raven Press; 1995: 177–201.
Evans RG: The role of radiation therapy in the treatment of brain tumors in children. In Brain Tumors: A Comprehensive Text. Edited by Morantz RA, Walsh JW. New York: Marcel Dekker; 1994: 659–677.
Thomas DGT: Neuro-oncology: Primary Malignant Brain Tumors. Edited by Thomas DGT. Baltimore: Johns Hopkins University Press; 1990: 165–167.
Punt J: Management of brain tumours in childhood. In Malignant Brain Tumours. Edited by Thomas DGT, Graham DI. London: Springer-Verlag; 1995: 177–192.
Barkovich AJ, Krischer J, Kun L, et al.: Brain stem gliomas: a classification system based on magnetic resonance imaging. Pediatr Neurosurg 1991, 16:73–83.
Sanford RA, Freeman CR, Burger P, et al.: Prognostic criteria for experimental protocols in pediatric brain stem gliomas. Surg Neurol 1988,30:276–280.
Hoffman HJ, Becker L, Craven MA: A clinically and pathologically distinct group of benign brain stem gliomas. Neurosurgery 1980, 7: 243–248.
Frank F, Fabrizi AP, Frank-Ricci R, et al.: Stereotactic biopsy and treatment of brain stem lesions: combined study of 33 cases (Bologna-Marseille). Acta Neurochir 1988, 42:177–181.
Artigas J, Ferszt R, Brock M, et al.: The relevance of pathological diagnosis for therapy and outcome of brain stem gliomas. Acta Neurochir 1988, 42:166–169.
Cohen ME, Duffner PK: Brain stem tumors. In Brain Tumors in Children. Principles of Diagnosis and Treatment. Edited by Cohen ME, Duffner PK. New York: Raven Press; 1995: 241–262.
Cohen ME, Duffner PK: Cerebellar Astrocytomas. In Brain Tumors in Children. Principles of Diagnosis and Treatment. Edited by Cohen ME, Duffner PK. New York: Raven Press; 1995: 203–218.
Garcia DM, Latifi HR, Simpson JR, et al.: Astrocytomas of the cerebellum in children. J Neurosurg 1989, 71:661–664.
Undijian S, Marinov M, Georgiev K: Long-term follow-up after surgical treatment of cerebellar astrocytomas in 100 children. Childs New Syst 1989, 5: 99–101.
Farwell JR, Dohrmann GJ, Flannery JT: Medulloblastoma in childhood: an epidemiological study. J Neurosurg 1984, 61: 593–664.
Tornita T, McClone DG: Medulloblastoma in childhood: results of radical resection and low-dose neuraxis radiation therapy. J Neurosurg 1986, 64: 238–242.
Evans AE, Jenkin DT, Sposto R, et al.: The treatment of medulloblastoma. Results of prospective randomized trial of radiation therapy with and without CCNU, vincristine, and prednisone. J Neurosurg 1990, 72:572–582.
Duffner PK, Horowitz ME, Krischer JP, et al.: Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med 1993, 328:1725–1731.
Packer RJ, Sutton LN, Goldwein JW, et al.: Improved survival with the use of adjuvant chemotherapy in the treatment of medulloblastoma. J Neurosurg 1991, 74:433–440.
Packer RJ: Diagnosis, treatment, and outcome of primary central nervous system tumors of childhood. Curr Opin Oncol 1994, 6: 240–246.
Kovnar EH, Kellie SJ, Horowitz ME, et al.: Preirradiation cisplatin and etoposide in the treatment of high-risk medulloblastomas and other malignant embryonal tumors of the central nervous system: A phase II study. J Clin Oncol 1990, 8:330–336.
Cohen ME, Duffner PK: Ependymomas. In Brain Tumors in Children. Edited by Cohen ME and Duffner PK. New York: Raven Press; 1995: 219–239.
Dohrmann GJ, Farwell JR, Flannery JT: Ependymomas and ependymoblastomas in children. J Neurosurg 1976, 45: 273–283.
Kingsley DPE, Kendall BE: The CT scanner in posterior fossa tumors of childhood. Br J Radiol 1979, 52: 769–776.
Healey EA, Barnes PD, Kupsky WJ, et al.: The prognostic significance of postoperative residual tumor in ependymoma. Neurosurg 1991, 28:666–671.
Kovnar E, Kun L, Krischer J: Patterns of dissemination and recurrence in childhood ependymoma: preliminary results of Pediatric Oncology Group protocol #8532. Ann Neurol 1991, 30: 457.
Goldwein JW, Leahy JM, Packer RJ, et al.: Intracranial ependymomas in children. Int J Radiat Oncol Biol Phys 1990, 19:1497–1502.
Bertolone SJ, Baum ES, Krivit W, et al.: A phase II study of cisplatin therapy in recurrent childhood brain tumors. J Neuro-oncol 1989, 7:5–11.
Gaynon PS, Ettinger LJ, Baum ES, et al.: Carboplatin in childhood brain tumors. Cancer 1990, 66:2465–2469.
Roach ES: Neurocutaneous syndromes. Pediatr Clin North Amer 1992, 39: 591–619.
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Fink, K.L., Rushing, E.J., Schold, S.C. (2003). Neuro-oncology. In: Rosenberg, R.N. (eds) Atlas of Clinical Neurology. Current Medicine Group, London. https://doi.org/10.1007/978-1-4757-4552-8_8
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