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Biochemical and Clinical Applications of Titration Calorimetry and Enthalpimetric Analysis

  • Albert C. Censullo
  • John A. Lynch
  • Dan H. Waugh
  • Joseph Jordan

Abstract

Several analytical methods based on adiabatic reaction calorimetry have been developed in recent years. Authoritative reviews of thermometric enthalpy titrations (including kinetic titrimetry), direct injection enthalpimetry and thermokinetic analysis are available.1–8 Applications to biochemical and clinical analysis8–20 have thus far been sporadic notwithstanding the fact that these fields are in dire need of instrumental methods. The relevant fundamental phenomenon (enthalpy change) is universal for all chemical reactions including biochemically and clinically important processes. Successful studies of biologically significant oxidation-reductions by titration calorimetry are reported in this paper. A new method, called “peak enthalpimetry,” is described and assessed in the context of contemporary requirements for instrumental approaches to clinical analysis. The use of novel Curie point temperature sensors for immunological determinations is discussed.

Keywords

Axial Ligand Carrier Stream Mercuric Nitrate Chloride Determination Integral Plot 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • Albert C. Censullo
    • 1
  • John A. Lynch
    • 1
  • Dan H. Waugh
    • 1
  • Joseph Jordan
    • 1
  1. 1.Department of Chemistry, 152 Davey LaboratoryThe Pennsylvania State UniversityUniversity ParkUSA

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