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Perinatal Damage to the Developing Brain

  • Chapter
Advances in Perinatal Medicine

Abstract

Prevention of perinatal damage to the developing brain is a major problem of modern neonatal intensive care. Our approach to this problem in the 1980s is aided by a considerable body of knowledge that has accumulated from diverse investigations over the past 20 years. Follow—up studies have documented the improvements in survival of infants of varying gestational ages and have identified with increasing accuracy those surviving neonates at highest risk of long—term neuro—developmental defects. Correlations between neonatal disease states and outcome have provided information on the relative importance of each neonatal complication in terms of brain damage. Recently, develop—mental neuroanatomy has given much needed information about the vulnerable areas of the neonatal brain at various stages of gestation. Human adult, neonatal, and experimental animal studies have provided additional valuable insights into the pathophysiology of the cerebral lesions seen in neonates. In the last few years, the development of radionucleotide, computed tomography, and ultrasound scans of the brain have enabled localization of at least some neonatal cerebral lesions in the living infant.

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  1. Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8

    Karen E. Pape & Pamela M. Fitzhardinge

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  1. Karen E. Pape
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Editors and Affiliations

  1. Harvard Medical School, Boston, Massachusetts, USA

    Aubrey Milunsky MB.B.Ch., M.R.C.P., D.C.H.  & Emanuel A. Friedman M.D.  & 

  2. Computational Mechanics Center, Boston, Massachusetts, USA

    Aubrey Milunsky MB.B.Ch., M.R.C.P., D.C.H.

  3. Massachusetts General Hospital, Boston, Massachusetts, USA

    Aubrey Milunsky MB.B.Ch., M.R.C.P., D.C.H.

  4. Beth Israel Hospital, Boston, Massachusetts, USA

    Emanuel A. Friedman M.D.

  5. University of California, San Diego, USA

    Louis Gluck M.D.

  6. School of Medicine, La Jolla, California, USA

    Louis Gluck M.D.

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© 1981 Aubrey Milunsky, Emanuel A. Friedman, and Louis Gluck

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Pape, K.E., Fitzhardinge, P.M. (1981). Perinatal Damage to the Developing Brain. In: Milunsky, A., Friedman, E.A., Gluck, L. (eds) Advances in Perinatal Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4451-4_2

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