Perinatal Damage to the Developing Brain

  • Karen E. Pape
  • Pamela M. Fitzhardinge


Prevention of perinatal damage to the developing brain is a major problem of modern neonatal intensive care. Our approach to this problem in the 1980s is aided by a considerable body of knowledge that has accumulated from diverse investigations over the past 20 years. Follow—up studies have documented the improvements in survival of infants of varying gestational ages and have identified with increasing accuracy those surviving neonates at highest risk of long—term neuro—developmental defects. Correlations between neonatal disease states and outcome have provided information on the relative importance of each neonatal complication in terms of brain damage. Recently, develop—mental neuroanatomy has given much needed information about the vulnerable areas of the neonatal brain at various stages of gestation. Human adult, neonatal, and experimental animal studies have provided additional valuable insights into the pathophysiology of the cerebral lesions seen in neonates. In the last few years, the development of radionucleotide, computed tomography, and ultrasound scans of the brain have enabled localization of at least some neonatal cerebral lesions in the living infant.


Cerebral Blood Flow Preterm Infant Cerebral Palsy Intraventricular Hemorrhage Intrauterine Growth Retardation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Aubrey Milunsky, Emanuel A. Friedman, and Louis Gluck 1981

Authors and Affiliations

  • Karen E. Pape
    • 1
  • Pamela M. Fitzhardinge
    • 1
  1. 1.Hospital for Sick ChildrenTorontoCanada

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