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Myocardial Infarct Size from Serum Cardiac Myosin Light Chain

Clinical and Experimental Studies
  • Y. Yazaki
  • R. Nagai
  • K. Yamaoki
  • S. Ueda

Abstract

The relationship between myocardial infarct size and serum cardiac light chain (LC) levels was studied in experimental and clinical myocardial infarction. In dogs with left anterior descending coronary artery occlusion, regression analysis showed good correlation between infarct size and LC II release, but CPK-MB release failed to correlate with infarct size because of a decreasing value of cumulative CPK with larger sized infarctions. In patients with acute myocardial infarction, Peak LC I levels correlated well with CPK release, since the phenomenon of the decreased CPK release in larger sized infarction was not so distinctive in human cases. Thus, LC determination may better qauntitate the extent of myocardial damage as well as provide a specific and sensitive method for diagnosis of acute myocardial infarction.

Keywords

Acute Myocardial Infarction Light Chain Coronary Occlusion Coronary Artery Occlusion Cardiac Myosin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Y. Yazaki
    • 1
  • R. Nagai
    • 1
  • K. Yamaoki
    • 1
  • S. Ueda
    • 1
  1. 1.Cardiovascular Research Unit, The Third Department of Internal Medicine, Faculty of MedicineUniversity of TokyoTokyo 113Japan

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