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Hypoxia, Calcium, and Contracture as Mediators of Myocardial Enzyme Release

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Advances in Myocardiology

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Abstract

During calcium-free perfusion, anoxic contracture of myocardial cells causes cells to separate at intercalated disks and leads to an energy-independent enzyme release in the absence of active transmembrane calcium fluxes. It is proposed that contracture mediates membrane damage and enzyme release in cells sensitized to the calcium paradox.

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References

  1. Hearse, D. J., Humphrey, S. M., and Bullock, G. R. 1978. The oxygen paradox and the calcium paradox: Two facets of the same problem? J. Mol. Cell. Cardiol. 10:641–668.

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  2. Muir, A. R. 1967. The effects of divalent cations on the ultrastructure of the perfused rat heart. J. Anat. 101:239–261.

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  3. Zimmerman, A. N. E., and Hulsmann, W. C. 1966. Paradoxical influence of calcium ions on the permeability of the cell membranes of the isolated rat heart. Nature211:646–647.

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Author information

Authors and Affiliations

  1. Department of Pathology, Northwestern University Medical School, Chicago, Illinois, 60611, USA

    C. E. Ganote, S. Y. Liu, S. Safavi & J. P. Kaltenbach

Authors
  1. C. E. Ganote
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  2. S. Y. Liu
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  3. S. Safavi
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  4. J. P. Kaltenbach
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Editor information

Editors and Affiliations

  1. Cardiology Research Center, Academy of Medical Sciences, Moscow, USSR

    E. Chazov M.D.

  2. Institute of Pathology, McGill University, Montreal, Quebec, Canada

    G. Rona M.D.

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© 1983 Springer Science+Business Media New York

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Ganote, C.E., Liu, S.Y., Safavi, S., Kaltenbach, J.P. (1983). Hypoxia, Calcium, and Contracture as Mediators of Myocardial Enzyme Release. In: Chazov, E., Saks, V., Rona, G. (eds) Advances in Myocardiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4441-5_29

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  • DOI: https://doi.org/10.1007/978-1-4757-4441-5_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-4443-9

  • Online ISBN: 978-1-4757-4441-5

  • eBook Packages: Springer Book Archive

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