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Hypoxia, Calcium, and Contracture as Mediators of Myocardial Enzyme Release

  • C. E. Ganote
  • S. Y. Liu
  • S. Safavi
  • J. P. Kaltenbach

Abstract

During calcium-free perfusion, anoxic contracture of myocardial cells causes cells to separate at intercalated disks and leads to an energy-independent enzyme release in the absence of active transmembrane calcium fluxes. It is proposed that contracture mediates membrane damage and enzyme release in cells sensitized to the calcium paradox.

Keywords

Enzyme Release Intercalate Disk Membrane Injury Sarcolemmal Membrane Calcium Paradox 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hearse, D. J., Humphrey, S. M., and Bullock, G. R. 1978. The oxygen paradox and the calcium paradox: Two facets of the same problem? J. Mol. Cell. Cardiol. 10:641–668.PubMedCrossRefGoogle Scholar
  2. 2.
    Muir, A. R. 1967. The effects of divalent cations on the ultrastructure of the perfused rat heart. J. Anat. 101:239–261.PubMedGoogle Scholar
  3. 3.
    Zimmerman, A. N. E., and Hulsmann, W. C. 1966. Paradoxical influence of calcium ions on the permeability of the cell membranes of the isolated rat heart. Nature211:646–647.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • C. E. Ganote
    • 1
  • S. Y. Liu
    • 1
  • S. Safavi
    • 1
  • J. P. Kaltenbach
    • 1
  1. 1.Department of PathologyNorthwestern University Medical SchoolChicagoUSA

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