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Inhibition of Vitamin D3-Induced Vascular Calcification by Carbocromen

  • E. Schraven
  • D. Trottnow
  • R. E. Nitz

Abstract

High doses of vitamin D3 induce myocardial lesions, necrotic alterations, and calcification of the vascular smooth muscle, (Mönckeberg arteriosclerosis) (6). These effects are accompanied by an increased calcium influx into the wall of the aorta and mesenterial vessels (1). Prophylactic application of MgCl2 nearly prevents this calcium overload, whereas KCl or calcium antagonists are less active. In our studies, the uptake of calcium-45 4 days after a single dose of vitamin D3 (90,000 IU/200 g) was increased in rat heart and aorta by a factor of 3 to 7, and up to 30-fold in mesenterial vessels. Application of carbocromen (10 mg/kg b.i.d.) for 4 days decreases the vitamin D3-induced radiocalcium uptake by 44 (aorta) to 67% (mesenterial vein), MgCl2 (15 mmol/kg b.i.d.) by 46 (mesenterial vein) to 92% (mesenterial artery), and verapamil (5 mg/kg b.i.d.) by 15 (aorta) to 44% (mesenterial vein).

Keywords

Vascular Smooth Muscle Mesenteric Artery Vascular Calcification Calcium Overload Myocardial Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • E. Schraven
    • 1
  • D. Trottnow
    • 1
  • R. E. Nitz
    • 1
  1. 1.Department of Medical Biological ResearchCassella AGFrankfurt/MainFederal Republic of Germany

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