Abstract
In the microcirculation, blood cannot be treated as a homogeneous fluid, but rather as a suspension. The individual cellular elements influence the hemodynamics. In this chapter, we shall study the behavior of red cells in microvessels. We will focus on the general features of cell-vessel interaction and their effect on the apparent viscosity of blood. Model experiments are used in these studies. In our models, the plasma is simulated by a silicone fluid, the red cells are simulated by gelatin pellets. With the model approach, apparent viscosity of blood in pulmonary capillaries is obtained. The Fahraeus-Lindqvist effect, Inversion of Fahraeus-Lindqvist effect, velocity distribution in microvessels, hematocrit in very narrow tubes, etc. are investigated.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barbee JJ, Cokelet GR: The Fahraeus effect, Microvas. Res., 3: 1–21, 1971.
Chien S, Dellenback RJ, Usami S, Gregersen MI: Plasma trapping in hematocrit determination. Differences among animal species, Proc. Soc. Exptl. Biol. Med., 119: 1155–1158, 1965.
Dientenfass L: Inversion of the Fahraeus Lindqvist phenomenon in blood flow through capillaries of diminishing radius, Nature, 215: 1099–1100, 1967.
Fahraeus R: The suspension stability of the blood, Physiol. Rev., 9: 241–274, 1929.
Fahraeus R, Lindqvist T: The viscosity of the blood in narrow capillary tubes, Am. J. Physiol., 96: 562–568, 1931.
Fung YC: Blood flow in the capillary bed, J. Biomech., 2: 353–373, 1969.
Fung YC, Sobin SS: Theory of sheet flow in the lung alveoli, J. Appl. Physiol., 26: 472–488, 1969.
Fung YC, Sobin SS: Pulmonary alveolar blood flow, Circ. Res., 30: 470–490, 1972.
Fung YC: Stochastic flow in capillary blood vessels, Microvascular Res., 5: 34–38, 1973.
Fung YC: Interaction of blood cells with vessel walls in microcirculation, Thrombosis Research, 8 (Suppl. II): 315–327, 1976.
Fung YC: Biomechanics: Mechanical Properties of Living Tissues, Springer-Verlag, New York, 1981.
Fung YC: Biodynamics: Circulation, Springer-Verlag, New York, 1984.
Fung YC: Biomechanics: Motion, Flow, Stress, and Growth, Springer-Verlag, New York, 1990.
Gaehtgens, P: Flow of blood through narrow capillaries: Rheological mechanisms determining capillary hematocrit and apparent viscosity, Biorheology J., 17: 183–189, 1980.
Goldsmith HL: Deformation of human red cells in tube flow, Biorheology, 7: 235–242, 1971.
Gregersen MI, Bryant CA, Hammerle WE, Usami S, Chien S: Flow characteristics of human erythrocytes through polycarbonate sieves, Science, 157: 825–827, 1967.
Lee JS: Slow viscous flow in a lung alveoli model: J. Biomech., 2: 187–198, 1969.
Lee JS, Fung YC: Modeling experiments of a single red blood cell moving in a capillary blood vessel, Microvascular Res., 1: 221–243, 1969.
Lew HS, Fung YC: Plug effect of erythrocytes in capillary blood vessels, Biophys. J., 10: 80–99, 1970.
Lipowsky HH, Usami S, Chien S: In vivo measurement of “apparent viscosity” and microvessel hematocrit in the mesentery of the cat, Microvascular Res., 19: 297–319, 1980.
Schmid-Schoenbein GW, Skalak R, Usami S, Chien S: Cell distribution in capillary networks, Microvascular Res., 19: 18–44, 1980.
Sheshadri V, Sutera SP: Concentration changes of suspensions of rigid spheres flowing through tubes, J. Colloid Interface Sci., 27: 101–110, 1968.
Skalak RA, Tozeren A, Zarda RP, Chien S: Strain energy function of red blood cell membrane, Biophys. J., 13: 245–246, 1973.
Sobin SS, Tremer HM, Fung YC: Morphometric basis of the sheet-flow concept of the pulmonary alveolar microcirculation in the cat, Circ. Res., 26: 397–414, 1970.
Sobin SS, Fung YC, Tremer H, Rosenquist TH: Elasticity of the pulmonary intervalveolar microvascular sheet in the cat, Circ. Res., 30: 440–450, 1972.
Sutera SR, Seshadri V, Croce PA, Hochmuth RM: Capillary blood flow II. Deformable model cells in tube flow, Microvascular Res., 2: 420–433, 1970.
Svanes J, Zweifach RW: Variations in small blood vessel hematocrits produced in hypothermic rats by micro-occlusion, Microvasc. Res., 1: 210–221, 1969.
Yen RT, Fung YC: Model experiments on apparent blood viscosity and hematocrit in pulmonary alveoli, J. Appl. Physiol, 35: 510–517, 1973.
Yen RT, Fung YC: Inversion of Fahraeus effect and effect of mainstream flow on capillary hematocrit, J. Appl. Physiol., 42 (4): 578–586, 1977.
Yen RT, Fung YC: Effect of velocity distribution on red cell distribution in capillary blood vessels, Am. J. Physiol., 235 (2): H251 - H257, 1978.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Yen, M.R.T. (1992). Model Studies of the Rheology of Blood in Microvessels. In: Hwang, N.H.C., Turitto, V.T., Yen, M.R.T. (eds) Advances in Cardiovascular Engineering. NATO ASI Series, vol 235. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4421-7_5
Download citation
DOI: https://doi.org/10.1007/978-1-4757-4421-7_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-3228-0
Online ISBN: 978-1-4757-4421-7
eBook Packages: Springer Book Archive