Introduction: Old Concepts — New Challenges

  • Benjamin W. Zweifach
Part of the NATO ASI Series book series (NSSA, volume 235)


Scientific research is in an era of expansion in which much of the dogma that we have been using as a frame of reference is being replaced by information at an extraordinarily complex level of molecular organization. The difficulties encountered in any given discipline are further compounded when as bioengineers an attempt is made to interpret data from the life sciences on the basis of the tools of a physical science. Our focus at this Conference is on Circulatory Dynamics and if one has to crystalize the ultimate organizational purpose of the Cardiovascular System, it is to nourish the population of cells that make up the various organs and tissues of the body. In that context, the heart and large arterial blood vessels serve only an ancillary role. The actual dynamics of this life-sustaining activity are accomplished by functional adjustments in the peripheral vessels lying within the tissue that is being supplied with blood. It is therefore fitting that this Conference should begin by focussing on the so-called “microcirculation.”


Ancillary Role Microcirculatory Network Cellular Building Block Spontaneous Vasomotor Milieu Interieur 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Bernard CL: Leçons de Pathologie experimentale, J. B. Bailbiere et Fils, Paris, 1880.Google Scholar
  2. 2.
    Cannon WB: The Wisdom of the Body, W. W. Norton, New York, 1932.Google Scholar
  3. 3.
    Malpighi M: De Pulmonibus: Observationes Anatomical, Bologna, 1661.Google Scholar
  4. 4.
    Zweifach BW: General principles governing behavior of the microcirculation, Amer. J. Med., 23: 684, 1957.PubMedCrossRefGoogle Scholar
  5. 5.
    Krogh A: The supply of oxygen to the tissues and the regulation of the capillary circulation, J. Physiol. (London), 52: 457, 1919.Google Scholar
  6. 6.
    Rouget C: Mémoire sur les développment, la structure et les proprietes physiologiques des capillaires sanguins et lymphatiiques, Arch. Physiol. Norm. Pathol., 5: 603, 1873.Google Scholar
  7. 7.
    Lewis T: The Blood Vessesls of the Human Skin and Their Responses, Shaw, Ltd., London, 1927.Google Scholar
  8. 8.
    Crone C: Modulation of solute permeability in microvascular endothelium, Fed. Proc., 45: 77, 1986.PubMedGoogle Scholar
  9. 9.
    Oda M, Azuma T, Watanabe N, Nishizahi Y, Nishida J, Ishii K, Suzuku H, Kaneko H, Somatsu H, Tsukada N, TsuchiyaM: Regulatory mechanisms of hepatic microcirculation-Involvement of contraction and dilation of sinudoids and sinusocidal endothelial fenestrae, In: Progress in Applied Microcirculation (Eds., Messmer K, Hammersen F.), Karger, Basel, 17 [Gastrointentinal Microcirculation], 103, 1990.Google Scholar
  10. 10.
    Tannenberg J: Ueber die Capillartâtigkeit, Zeit. f. allg Path u Path. Anat., 36: 374, 1925.Google Scholar
  11. 11.
    Schmid-Schönbein GW, Skalak R, Chien S: Hemodynamics in arterial networks, In: The Resistance Vasculature (Eds., Bevan JA, Halpern W, Mulvany MJ ), Humana Press, New Jersey, 1991.Google Scholar
  12. 12.
    Carrier EB: Observations of living cells in the bat’s wing, In: Physiological Papers Dedicated to A. Krogh, 1–9, Levin and Munkgaard, Copenhagen, 1926.Google Scholar
  13. 13.
    Landis EM: Micro-injection studies of capillary permeability. II. Relationship between capillary pressure and the rate at which fluid passes through the capillary walls of single capillaries, Amer. J. Physiol., 82: 217, 1927.Google Scholar
  14. 14.
    Ludwig C: Die physiologischen Leistungen des Blutdruckes, Airzel, Leipzig, 1865.Google Scholar
  15. 15.
    Starling EH: On the absorption of fluids from the connective tissue spaces, J. Physiol. (London), 312, 1896.Google Scholar
  16. 16.
    Chambers R, Zweifach BW: Capillary endothelial cement in relation to permeability, J. Cell. Comp. Physiol., 15: 255, 1940.CrossRefGoogle Scholar
  17. 17.
    Simionescu M, Ghitescu L, Fixman A, Simionescu N: How plasma macromolecules croos the endothelium, N.I.P.S., 2: 97, 1987.Google Scholar
  18. 18.
    Mehta LL, Lawton DL, Nicolini FA, Ross HM, Player DW: Effects of activated polymorphonuclear leukocytes on vascular smooth muscle tone, Amer. J. Physiol., 261 [Ht. Circ. Physiol. 30]:H-327, 1991.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Benjamin W. Zweifach
    • 1
  1. 1.Ames-BioengineeringUniversity of California, San DiegoLa JollaUSA

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