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Effects of Pancreas Transplantation on Secondary Complications of Diabetes

  • Paola Fioretto
  • Michael Mauer
  • Arthur W. Walsh
  • Michael D. Elliott
  • Michael Chen
  • Dixon B. Kaufman
  • Xavier Navarro
  • William R. Kennedy
  • A. Osama Gaber
  • Ann Cashion
  • Donna Hathaway
  • Hosein Shokouh-Amiri

Abstract

Diabetic nephropathy (DN) is the leading cause of end stage renal disease (ESRD) in the Western world, responsible for more than 44% of new ESRD cases in the United States.1 Type 2 diabetes is currently responsible for the large majority of diabetic ESRD patients.2 Among patients with type 1 diabetes, 25% to 35% ultimately develop severe DN and a similar risk is found by long-term survivors of type 2 diabetes.2 Despite the beneficial effects of antihypertensive agents, in slowing the rate of progression of overt diabetic nephropathy,3–5 the number of diabetic patients requiring renal replacement therapy is substantially and continuously increasing.1 Thus, any therapeutic intervention able to reduce the risk of ESRD in diabetes can provide benefits in terms of mortality, morbidity, quality of life of patients, and healthcare costs.

Keywords

Diabetic Nephropathy Diabetic Retinopathy Macular Edema Diabetic Neuropathy Proliferative Diabetic Retinopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Paola Fioretto
  • Michael Mauer
  • Arthur W. Walsh
  • Michael D. Elliott
  • Michael Chen
  • Dixon B. Kaufman
  • Xavier Navarro
  • William R. Kennedy
  • A. Osama Gaber
  • Ann Cashion
  • Donna Hathaway
  • Hosein Shokouh-Amiri

There are no affiliations available

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