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Immunology in Pancreas Transplantation

  • Rainer W. G. Gruessner
  • George W. BurkeIII
  • Gaetano Ciancio
  • Rolando García-Morales
  • Joshua Miller

Abstract

Type 1 diabetes mellitus is considered a chronic autoimmune disorder (see chapter 2). The autoimmune etiology is based on several independent findings, including (1) the presence of a lymphocytic infiltrate in the islets (“isletitis”), (2) the appearance of a series of autoantibodies coupled with progressive loss of insulin secretion, (3) the specificity of pancreatic β-cell destruction, and (4) recurrence of type 1 diabetes mellitus in patients transplanted with identical-twin pancreas grafts in the absence of immunosuppressive therapy. In addition, several small-animal models lend support to the autoimmune etiology of type 1 diabetes mellitus: The two most extensively studied models are the BB rat and the nonobese diabetic mouse (NOD). A detailed discussion on diabetic autoimmunity in small animals is provided in chapter 5.1.

Keywords

Pancreas Transplant Donor Bone Marrow Mixed Chimerism Pancreas Graft Polymerase Chain Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Rainer W. G. Gruessner
  • George W. BurkeIII
  • Gaetano Ciancio
  • Rolando García-Morales
  • Joshua Miller

There are no affiliations available

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