Skip to main content

Multiple New Isoforms of the Human Prolactin Receptor Gene

  • Conference paper
Protecting Infants through Human Milk

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 554))

Abstract

Prolactin (PRL) is a polypeptide hormone with a clear role in promoting mammary gland growth, differentiation, and lactogenesis. In addition, endocrine and/or autocrine/ paracrine PRL (Clevenger et al. 1995; Ginsburg & Vonderhaar 1995) promotes mammary carcinogenesis in rodents (Wennbo et al. 1997) and also may contribute to the initiation and progression of human breast cancer (Hankinson et al. 1999).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bignon C, Binart N, Ormandy C, Schuler LA, Kelly PA, Djiane J. Long and short forms of the ovine prolactin receptor: cDNA cloning and genomic analysis reveal that the two forms arise by different alternative splicing mechanisms in ruminants and in rodents. J Mol Endocrinol 1997;19:109–120.

    Article  PubMed  CAS  Google Scholar 

  • Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA. Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev 1998;19:225–268.

    Article  PubMed  CAS  Google Scholar 

  • Boutin JM, Jolicoeur C, Okamura H, Gagnon J, Edery M, Shirota M, Banville D, Dusanter-Fourt I, Djiane J, Kelly PA. Cloning and expression of the rat prolactin receptor, a member of the growth hormone/prolactin receptor gene family. Cell 1988;53:69–77.

    Article  PubMed  CAS  Google Scholar 

  • Boutin JM, Edery M, Shirota M, Jolicoeur C, Lesueur L, Ali S, Gould D, Djiane J, Kelly PA. Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cells. Mol Endocrinol 1989;3:1455–1461.

    Article  PubMed  CAS  Google Scholar 

  • Clevenger CV, Chang WP, Ngo W, Pasha TL, Montone KT, Tomaszewski JE. Expression of prolactin and prolactin receptor in human breast carcinoma. Evidence for an autocrine/paracrine loop. Am J Pathol 1995;146:695–705.

    PubMed  CAS  Google Scholar 

  • Davis JA, Linzer DI. Expression of multiple forms of the prolactin receptor in mouse liver. Mol Endocrinol 1989;3:674–680.

    Article  PubMed  CAS  Google Scholar 

  • Ginsburg E, Vonderhaar BK. Prolactin synthesis and secretion by human breast cancer cells. Cancer Res 1995;55:2591–2595.

    Google Scholar 

  • Hankinson SE, Wille WC, Michaud DS, Manson JE, Colditz GA, Longcope C, Rosner B, Speizer FE. Plasma prolactin levels and subsequent risk of breast cancer in postmenopausal women. J Natl Cancer Inst 1999;91:629–634.

    Article  PubMed  CAS  Google Scholar 

  • Hu ZZ, Zhuang L, Meng J, Leondires M, Dufau ML. The human prolactin receptor gene structure and alternative promoter utilization: the generic promoter hPIII and a novel human promoter hP(N). J Clin Endocrinol Metab 1999;84:1153–1156.

    Article  PubMed  CAS  Google Scholar 

  • Hu ZZ, Zhuang L, Meng J, Tsai-Morris CH, Dufau ML. Complex 5’ genomic structure of the human prolactin receptor: multiple alternative exons 1 and promoter utilization. Endocrinology 2002;143:2139–2142.

    Article  PubMed  CAS  Google Scholar 

  • Kelly PA, Boutin JM, Jolicoeur C, Okamura H, Shirota M, Edery M, Dusanter-Fourt I, Djiane J. Purification, cloning, and expression of the prolactin receptor. Biol Reprod 1989;40:27–32.

    Article  PubMed  CAS  Google Scholar 

  • Kline JB, Roehrs H, Clevenger CV. Functional characterization of the intermediate isoform of the human prolactin receptor. J Biol Chem 1999;274:35461–35468.

    Article  PubMed  CAS  Google Scholar 

  • Ormandy CJ, Binart N, Helloco C, Kelly PA. Mouse prolactin receptor gene: genomic organization reveals alternative promoter usage and generation of isoforms via alternative 3’-exon splicing. DNA Cell Biol 1998;17:761–770.

    Article  PubMed  CAS  Google Scholar 

  • Trott JF, Hovey RC, Koduri S, Vonderhaar BK. Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein. J Mol Endocrinol 2003;30:31–47.

    Article  PubMed  CAS  Google Scholar 

  • Vonderhaar BK. Prolactin involvement in breast cancer. Endocr Relat Cancer 1999;6:389–404.

    Article  PubMed  CAS  Google Scholar 

  • Wennbo H, Gebre-Medhin M, Gritli-Linde A, Ohlsson C, Isaksson OG, Torneil J. Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice. J Clin Invest 1997;100:2744–2751.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer Science+Business Media New York

About this paper

Cite this paper

Trott, J.F., Hovey, R.C., Koduri, S., Vonderhaar, B.K. (2004). Multiple New Isoforms of the Human Prolactin Receptor Gene. In: Pickering, L.K., Morrow, A.L., Ruiz-Palacios, G.M., Schanler, R.J. (eds) Protecting Infants through Human Milk. Advances in Experimental Medicine and Biology, vol 554. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4242-8_71

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-4242-8_71

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3461-1

  • Online ISBN: 978-1-4757-4242-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics