Transmission of Cytomegalovirus (CMV) through Human Milk
Nine out of ten mothers with positive cytomegalovirus (CMV) serology shed CMV in their milk at some time during lactation. CMV is transmitted readily through human milk. Although the majority of acquired CMV infections cause little or no symptoms, there is an association between CMV infection and severe disease in small premature infants. Pasteurization damages some of the anti-infective properties of untreated human milk but is the only reliable and feasible method to destroy CMV infectivity. The current practice of feeding untreated human milk may require reevaluation for seropositive mothers of very immature infants.
KeywordsBreast Milk Human Milk Cytomegalovirus Infection Healthy Term Infant Systemic Bacterial Infection
Unable to display preview. Download preview PDF.
- Gambarotto K, Ranger-Rogez S, Aubard Y, Piver P, Duffetelle B, Delpeyroux C, Roussanne MC, Nicot T, Denis F. [Primary cytomegalovirus infection and pregnant women: epidemiological study on 1100 women at Limoges]. Pathol Biol (Paris) 1997;45:453–461.Google Scholar
- Pana A, Santi AL, Grassi M, Divizia M, Assumma M, Carratu A. On the presence of cytomegalovirus in the milk of normal women; correlation between breast feeding and virus excretion in infants. Boll 1st Sieroter Milan 1981;60:85–88.Google Scholar
- Stagno S. Cytomegalovirus. In: Remington JS, Klein JO, editors. Infectious Diseases of the Fetus and Newborn Infant. Philadelphia: WB Saunders, 1995.Google Scholar
- Wu J, Tang ZY, Wu YX, Li WR. Acquired cytomegalovirus infection of breast milk in infancy. Chin Med J (Engl) 1989;102:124–128.Google Scholar