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Human Milk Oligosaccharide Blood Group Epitopes and Innate Immune Protection against Campylobacter and Calicivirus Diarrhea in Breastfed Infants

  • A. L. Morrow
  • G. M. Ruiz-Palacios
  • M. Altaye
  • X. Jiang
  • M. L. Guerrero
  • J. K. Meinzen-Derr
  • T. Farkas
  • P. Chaturvedi
  • L. K. Pickering
  • D. S. Newburg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 554)

Abstract

Human milk contains a variety of bioactive agents, including oligosaccharides, which are part of the innate defense system (Hanson et al. 1991; Zopf & Roth 1996; Newburg et al. 1998; Erney et al. 2000; Hamosh 2001; Chaturvedi et al. 2001). Oligosaccharides are the third largest solid constituent of human milk after lactose and lipids (Stahl et al. 1994; Zopf & Roth 1996; Erney et al. 2000; Chaturvedi et al. 2001; Hamosh 2001). α 1,2-Linked fucosylated oligosaccharides in human milk have been shown to inhibit host ligand binding to Campylobacter, caliciviruses, and other enteric pathogens (Newburg et al. 1990; Crane et al. 1994; Marionneau et al. 2002; Ruiz-Palacios et al. 2003; Huang et al. 2003). Significant variation exists between mothers in the quantity of α 1,2-linked fucosylated oligosaccharides in their milk. We conducted this study in breastfed infants to determine the clinical relevance of the observed variation in human milk fucosylated oligosaccharides in relation to protection offered infants against diarrhea due to Campylobacter jejuni and caliciviruses.

Keywords

Human Milk Breastfed Infant Milk Oligosaccharide Human Milk Oligosaccharide Diarrhea Episode 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • A. L. Morrow
    • 1
  • G. M. Ruiz-Palacios
    • 2
  • M. Altaye
    • 1
  • X. Jiang
    • 1
  • M. L. Guerrero
    • 2
  • J. K. Meinzen-Derr
    • 1
  • T. Farkas
    • 1
  • P. Chaturvedi
    • 3
  • L. K. Pickering
    • 4
  • D. S. Newburg
    • 3
  1. 1.Center for Epidemiology & Biostatistics (ALM, MA, JKM-D) and Division of Infectious Diseases (XJ, TF)Cincinnati Children’s Hospital Medical CenterCincinnatiUSA
  2. 2.Departamento de InfectologéaInstituto Nacional de Ciencias Médicas y NutriciónMéxico CityMéxico
  3. 3.Program in Glycobiology, Shriver CenterUniversity of Massachusetts Medical SchoolWalthamUSA
  4. 4.National Immunization ProgramCenters for Disease Control and PreventionAtlantaUSA

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