Morphogenesis of Mammary Gland Development
Development of the mammary gland in females is a dynamic, orchestrated process that occurs throughout postnatal development. Initiated during embryogenesis, epithelial cells advance into the underlying stromal matrix to form a primitive rudimentary structure. With the onset of puberty this anlage then responds to hormonal and local cues to rapidly establish a ductal network. Whereas in mice this network is relatively simple, in humans there is significantly more branching morphogenesis to develop terminal duct lobular unit structures. With the onset of pregnancy and associated changes in the hormonal and local environment, alveolar development progresses to establish a gland that is densely filled with alveolar structures by the end of pregnancy. Concomitantly, mammary epithelial cells within the gland begin to attain their unique ability to synthesize various milk constituents, such that by parturition, functional lactogenesis can be realized.
KeywordsMammary Gland Hepatocyte Growth Factor Mammary Gland Development Alveolar Development Mammary Stroma
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- Daniel CW, Silberstein G. Postnatal development of the rodent mammary gland. In: Neville MC, Daniel CW, editors. The Mammary Gland: Development, Regulation, and Function. New York: Plenum Press, 1987; pp 3–36.Google Scholar
- Grimm SL, Seagroves TN, Kabotyanski EB, Hovey RC, Vonderhaar BK, Lydon JP, Miyoshi K, Hennighausen L, Ormandy CJ, Lee AV, Stull MA, Wood TL, Rosen JM. Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development. Mol Endocrinol 2002;16:2675–2691.PubMedCrossRefGoogle Scholar
- Hadsell DL. Genetic manipulation of mammary gland development and lacation. In: Pickering LK, Morrow AL, Ruiz-Palacios GM, Schanler RJ. Protecting Infants through Human Milk: Advancing the Scientific Evidence. Advances in Experimental Medicine and Biology Series. New York: Kluwer Academic/Plenum Publishers, 2004; this volume.Google Scholar
- Hovey RC, Trott JF, Ginsburg E, Goldhar A, Sasaki MM, Fountain SJ, Sundararajan K, Vonderhaar BK. Transcriptional and spatiotemporal regulation of prolactin receptor mRNA and cooperativity with progesterone receptor function during ductal branch growth in the mammary gland. Dev Dyn 2001b;222:192–205.PubMedCrossRefGoogle Scholar
- Russo J, Russo IH. Development of the human mammary gland. In: Neville MC, Daniel CW, editors. The Mammary Gland: Development, Regulation, and Function. New York: Plenum Press, 1987; pp 67–93.Google Scholar
- Vonderhaar BK. Hormones and growth factors in mammary gland development. In: Veneziale CM, editor. Control of Cell Growth and Proliferation. New York: Van Noostrand, Reinhold, 1984; pp 11–33.Google Scholar