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Prevention of Stroke pp 49–63Cite as

Regression of Atherosclerosis

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Abstract

Several studies carried out on animal models indicate regression of experimental atherosclerosis after the return to a normal or hypocaloric diet, either alone or in combination with various drugs.1–6 However, pathoanatomic, epidemiologic, and clinical studies in man on this subject are not unanimous.7–10 Arguments in favor of regression of atherosclerosis in man are:

  1. 1.

    The capacity of arteries to adapt and to recover from previous lesions;

  2. 2.

    The inflammatory rather than degenerative nature of atherosclerosis;

  3. 3.

    The slow and variable course of the disease from its onset in early infancy to senescence;

  4. 4.

    The encouraging results of animal experiments and, recently, of plasmapheresis in homozygous and heterozygous patients with low-density lipoprotein (LDL) receptor abnormalities.

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  1. Michael G. Hennerici
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Editors and Affiliations

  1. Department of Neurology, Sunnybrook Health Science Centre, University of Toronto, Toronto, Ontario, M4N 3M5, Canada

    John W. Norris M.D.

  2. Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, N6A 5A5, Canada

    Vladimir C. Hachinski M.D.

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Hennerici, M.G. (1991). Regression of Atherosclerosis. In: Norris, J.W., Hachinski, V.C. (eds) Prevention of Stroke. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4226-8_4

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