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Cerebrospinal Fluid

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Pediatric Nuclear Medicine

Abstract

Sensitive, elegant assessments of normal and abnormal cerebrospinal fluid (CSF) dynamics can be obtained with relatively straightforward planar scintigraphy, and they deserve consideration as diagnostic tools for disorders affecting the CSF. The introduction of computed tomography (CT) and later magnetic resonance imaging (MRI) has resulted in a reduction in the use of radionuclide cisternography. The method continues to be used in conjunction with clinical examination, structural imaging, and other neurological procedures in children to aid in the evaluation of selected clinical problems, such as evaluation of shunt function in the treated hydrocephalic patient.

Some of the concepts and portions of the wording in this chapter were contributed by K. Welch, M.D., formerly Professor of Surgery at Harvard Medical School and Chairman of the Department of Neurosurgery at Children’s Hospital, who was a coauthor of this chapter in the First Edition of Pediatric Nuclear Medicine.

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References

  1. Ashbum WL, Harbert JC, Briner WH. Cerebrospinal fluid rhinorrhea studied with the gamma scintillation camera. J Nucl Med 1968;9:523

    Google Scholar 

  2. Bannister R, Gilford E, Kocen R. Isotope encephalography in the diagnosis of dementia due to communicating hydrocephalus. Lancet 1967;2:1014–1017

    Article  PubMed  CAS  Google Scholar 

  3. Benson DF, Lemay M, Patten DH, Rubens AB. Diagnosis of normal pressure hydrocephalus. N Engl J Med 1970;283:609–615

    Article  PubMed  CAS  Google Scholar 

  4. Bonting SL, Simon KA, Hawkins NM. Studies of sodium potassium activated adenosine triphosphatase. Arch Biochem Biophys 1961;95:416–423

    Article  PubMed  CAS  Google Scholar 

  5. Caldicott W, Northe JB, Simpson DA. Traumatic cerebrospinal fluid fistulas in children. J Neurosurg 1973;38:1–9

    Article  PubMed  CAS  Google Scholar 

  6. Cowan RJ, Maynard CD. Trauma to the brain and extracranial structures. Semin Nucl Med 1974; 4:319–338

    Article  PubMed  CAS  Google Scholar 

  7. Cserr HE Physiology of the choroid plexus. Physiol Rev 1971;51:273–311

    PubMed  CAS  Google Scholar 

  8. Cutler R, Page L, Galicich J, Watters GV. Formation and absorbtion of cerebrospinal fluid in man. Brain 1968;91:707–720

    Article  PubMed  CAS  Google Scholar 

  9. Davson H, Welch K, Segal MB. The Physiology and Pathophysiology of the Cerebrospinal Fluid. Edinburgh: Churchill Livingstone, 1987

    Google Scholar 

  10. DeRougement J, Ames AI, Nesbett FB, Hofmann HF. Fluid formed by choroid plexus: a technique for its collection and a comparison of its electrolyte composition with serum and cisternal fluids. J Neurophysiol 1960;23:485–495

    Google Scholar 

  11. DiChiro G. Movement of the cerebrospinal fluid in human beings. Nature 1964;204:290–291

    Article  Google Scholar 

  12. Donn SM, Roloff DW, Keyes J. Lumbar cisternography in evaluation of hydrocephalus in the preterm infant. Pediatrics 1983;172:670–676

    Google Scholar 

  13. Eisenberg HM, McComb JG, Lorenzo AV. Cerebrospinal fluid overproduction and hydrocephalus associated with a choroid plexus papilloma. J Neurosurg 1974;40:381–385

    Article  PubMed  CAS  Google Scholar 

  14. Ferreira S, Jhingram SG, Johnson PC. Radionuclide cisternography for the study of arachnoid cysts: a case report. Neuroradiology 1980;19:167–169

    Article  PubMed  CAS  Google Scholar 

  15. Front D. Minderhoud JM, Beks JW, Penning L. Leptomeningeal cysts diagnoses by isotope cisternography. J Neurol Neurosurg Psychiatry 1973; 36:1018–1023

    Article  PubMed  CAS  Google Scholar 

  16. Gelfand M, Walus M, Tomsick T, Benton C, McLaurin R. Nasoethmoidal encephalomeningocele demonstrated by cisternography: case report. J Nucl Med 1977;18:706–708

    PubMed  CAS  Google Scholar 

  17. Glasaue FE, Alker GJ, Leslie EV, Nicol CF. Isotope cisternography in hydrocephalus with normal pressure: case report and technical note. J Neurosurg 1968;29:555–561

    Article  Google Scholar 

  18. Greitz T, Grepe A. Encephalography in the diagnosis of convexity block hydrocephalus. Acta Radiol [Diagn] (Stock) 1971;11:232–242

    CAS  Google Scholar 

  19. Harbert J, Haddad D, McCullough D. Quantitation of cerebrospinal fluid shunt flow. Radiology 1974; 112:379–387

    PubMed  CAS  Google Scholar 

  20. Harwood-Nash DC. Fractures of the petrous and tympanic parts of the temporal bone in children: a tomographic study of 35 cases. Am J Roentgenol 1970;110:598–607

    Article  CAS  Google Scholar 

  21. Jackson RT, Tigges J, Arnold W. Subarachnoid space of the CNS, nasal mucosa, and lymphatic system. Arch Otolaryngol 1979;105:180–184

    Article  PubMed  CAS  Google Scholar 

  22. Jaffe B, Welch K, Strand R, Treves S. Cerebrospinal fluid rhinorrhea via the fossa of Rosenmüller. Laryngoscope 1976;86:903–907

    Article  PubMed  CAS  Google Scholar 

  23. Johanson CE. The choroid plexus-arachnoid mem-brane-cerebrospinal fluid system. In Boulton AA, Baker GB, Walz W (eds): Neuromethods; The Neuronal Microenvironment. Clifton, NJ: Humana Press, 1988:33–104

    Chapter  Google Scholar 

  24. Johnson RT. Clinicopathological aspects of the cerebrospinal fluid circulation. In Wolstenholme GEW, O’Connor CM (eds): CIBA Foundation Symposium on Production, Circulation and Absorption of the Cerebrospinal Fluid. Boston: Little Brown, 1958: 265–278

    Google Scholar 

  25. Kaplan WD, McComb JG, Strand RD, Treves ST. Suppression of 99mTc -pertechnetate uptake in a choroid plexus papilloma. Radiology 1973;109:395–396

    PubMed  CAS  Google Scholar 

  26. Khan EA, Luros JT. Hydrocephalus from overproduction of cerebrospinal fluid. J Neurosurg 1952; 9:59–67

    Article  Google Scholar 

  27. Kuruc A, Treves S, Welch K, Merlino D. Radionuclide estimation of cerebral spinal fluid shunt flow: evidence supporting an alternative theoretical model. J Neurosurg 1984;60:361–364

    Article  PubMed  CAS  Google Scholar 

  28. Lantz EJ, Forbes GS, Brown ML, Laws ER. Radiology of cerebrospinal fluid rhinorrhea. AJR 1980;135:1023–1030

    Article  PubMed  CAS  Google Scholar 

  29. Lorenzo AV, Page LK, Watters GV. Relationships between cerebrospinal fluid formation, absorption and pressure in human hydrocephalus. Brain 1970;93:679–692

    Article  PubMed  CAS  Google Scholar 

  30. Lusins J, Nakagawa H, Sorek M, Goldsmith S. Cisternography and CT scanning with 111InDTPA in evaluation of posterior fossa arachnoid cysts. Clin Nucl Med 1979;4:161–163

    Article  PubMed  CAS  Google Scholar 

  31. Marinov M, Undjian S, Wetzka P. An evaluation of the surgical treatment of intracranial arachnoid cysts in children. Childs Nerv Syst 1989;5:177–183.

    Article  PubMed  CAS  Google Scholar 

  32. Matson DD. Hydrocephalus in a premature infant caused by papilloma of the choroid plexus: with report of surgical treatment. J Neurosurg 1953; 10:416–420.

    Article  PubMed  CAS  Google Scholar 

  33. Matson DD, Crofton FDL. Papilloma of the choroid plexus in childhood. J Neurosurg 1960; 17:1002–1027

    Article  PubMed  CAS  Google Scholar 

  34. McComb JG, Hyman S, Weiss MH. Lymphatic drainage of cerebrospinal fluid in the cat. In Shapiro K, Marmarou A, Portnoy H (eds): Hydrocephalus. New York: Raven Press, 1984

    Google Scholar 

  35. McLennan JE, Mickcle JP, Treves ST. Radionuclide cysternographic evaluation and follow-up of posttraumatic subconjunctival CSF loculation. J Neurosurg 1976;44:496–499

    Article  PubMed  CAS  Google Scholar 

  36. Milhorat TH. Structure and function of the choroid plexus and other sites of cerebrospinal fluid formation. Int Rev Cytol 1976;47:225–288

    Article  PubMed  CAS  Google Scholar 

  37. Netsky MG, Shuangshoti S. The Choroid Plexus In Health and Disease. Charlottesville: University Press of Virginia, 1975

    Google Scholar 

  38. O’Brien MD, Haggith JW, Appleton D. Cerebrospinal fluid dynamics in dementia. Exp Brain Res Suppl 1982;5:196–200

    Article  Google Scholar 

  39. Page LK, Bresnan MJ, Lorenzo AV. Cerebrospinal fluid perfusion studies in childhood hydrocephalus. Surg Neurol 1973;1:317–320

    PubMed  CAS  Google Scholar 

  40. Price DL, James A, Sperber E, Strecker ER Communicating hydrocephalus: cisternographic and neuropathologic studies. Arch Neurol 1976;33: 15–20

    Article  PubMed  CAS  Google Scholar 

  41. Rau H, Flas A, Horst W, Baumgartner G. Clinical observations on communicating hydrocephalus of unknown etiology. J Neurol 1974;207:279–287

    Article  PubMed  CAS  Google Scholar 

  42. Ray BS, Peck FC. Papilloma of the choroid plexus of the lateral ventricles causing hydrocephalus in an infant. J Neurosurg 1956;13:405–110

    Google Scholar 

  43. Rubin RC, Henderson ES, Ommaya AK, Walker MD, Rail DP. The production of cerebrospinal fluid in man and its modification by acetazolamide. J Neurosurg 1966;25:430–436

    Article  PubMed  CAS  Google Scholar 

  44. Rudd TG, Shurtleff DB, Loeser JD, Nelp WB. Radionuclide assessment of cerebrospinal fluid shunt function in children. J Nucl Med 1973;14:683–686

    PubMed  CAS  Google Scholar 

  45. Shenkin HA, Crowley JN. Hydrocephalus complicating pituitary adenoma. J Neurol Neurosurg Psychiatry 1973;36:1063–1068

    Article  PubMed  CAS  Google Scholar 

  46. Spector R, Johanson CE. The mammalian choroid plexus. Sci Amr 1989;261:68–74

    Article  CAS  Google Scholar 

  47. Stehling MJK, Firth JL, Guilfoyle DN, et al. Observation of cerebrospinal fluid flow with echo-planar magnetic resonance imaging. Br J Radiol 1991;64:89–97

    Article  PubMed  CAS  Google Scholar 

  48. Tator CH, Murray S. A clinical, pneumoencephalo-graphic and radioisotopic study of normal-pressure communicating hydrocephalus. Can Med Assoc J 1971;105:573–579

    PubMed  CAS  Google Scholar 

  49. Treves ST, Welch K, Kuruc A. Cerebrospinal fluid. In Treves ST (ed): Pediatric Nuclear Medicine. New York: Springer-Verlag, 1985:223–231

    Google Scholar 

  50. Vates TAJ, Bonting SL, Oppelt WW. Na-K activated adenosine triphosphatase formation of cerebrospinal fluid in the cat. Am J Physiol 1964;206:1165–1167

    PubMed  CAS  Google Scholar 

  51. Welch K. Secretion of cerebrospinal fluid by choroid plexus of the rabbit. Am J Physiol 1963;205:617–624

    PubMed  CAS  Google Scholar 

  52. Winston K, Hall J, Johnson D, Micheli L. Acute elevation of intracranial pressure following transection of non-functional spinal cord. Clin Orthop 1977; 128:41–44

    PubMed  Google Scholar 

  53. Wocjan J, Klisiewicz R, Krolicki L. Overpressure radionuclide cisternography and metrizamide computed tomographic cisternography in the detection of intermittent rhinoliquorrheas in children. Childs Nerv Syst 1989;5:238–240

    Article  PubMed  CAS  Google Scholar 

  54. Wright EM. Transport processes in the formation of the cerebrospinal fluid. Rev Physiol Biochem Pharmacol 1978;83:1–34

    CAS  Google Scholar 

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Treves, S.T., O’Tuama, L.A., Kuruc, A. (1995). Cerebrospinal Fluid. In: Treves, S.T. (eds) Pediatric Nuclear Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4205-3_7

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  • DOI: https://doi.org/10.1007/978-1-4757-4205-3_7

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-4207-7

  • Online ISBN: 978-1-4757-4205-3

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