Early Development of the Human Placenta

  • Kurt Benirschke
  • Peter Kaufmann


Understanding placental pathology demands only a limited knowledge of implantation and early placental development, as disturbances of these early steps of placentation cause abortion, rather than affecting placental structure and function. For this reason, only basic information concerning the early development is presented in this chapter. The pathologically interesting interactions between implantation site and the shape of the placenta will be dealt with in Chapter 14.


Basal Lamina Human Placenta Apical Plasma Membrane Uterine Epithelium Uterine Epithelial Cell 


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  1. Bargmann, W., and Knoop, A.: Elektronenmikroskopische Untersuchungen an Plazentazotten des Menschen. Bemerkungen zum Synzytiumproblem. Z. Zellforsch. 50:472–493, 1959.PubMedCrossRefGoogle Scholar
  2. Benirschke, K.: In, Fetal Homeostasis, Vol. I. R.M. Wynn, ed. p. 328, New York Academy of Sciences, Sci., New York, 1965.Google Scholar
  3. Boyd, J.D., and Hamilton, W.J.: The Human Placenta. Heffer & Sons, Cambridge 1970.Google Scholar
  4. Castellucci, M., Scheper, M., Scheffen, I., Celona, A., and Kaufmann, P.: The development of the human placental villous tree. Anat. Embryol. (Berl.) 181: 117–128, 1990.CrossRefGoogle Scholar
  5. Dallenbach-Hellweg, G., and Sievers, S.: Die histologische Reaktion des Endometrium auf lokal applizierte Gestagene. Virchows Arch. [Pathol Anat.] 368: 289–298, 1975.CrossRefGoogle Scholar
  6. Demir, R., Kaufmann, P., Castellucci, M., Erbengi, T., and Kotowski, A.: Fetal vasculogenesis and angiogen-esis in human placental villi. Acta Anat (Basel) 136: 190–203, 1989.CrossRefGoogle Scholar
  7. Dempsey, E.W.: The development of capillaries in the villi of early human placentas. Am. J. Anat. 134: 221–238, 1972.PubMedCrossRefGoogle Scholar
  8. Denker, H.-W.: Implantation: the role of proteinases, and blockage of implantation by proteinase inhibitors. Adv. Anat. Embryol. Cell. Biol. 53:3–123, 1977.PubMedGoogle Scholar
  9. Denker, H.-W.: Embryo implantation and trophoblast invasion. In, Cell Movement and Neoplasia. M. de Brabander, ed., pp. 151–162. Pergamon Press, Oxford, 1980.Google Scholar
  10. Denker, H.-W.: Trophoblast-endometrial interactions at embryo implantation: a cell biological paradox. Trophoblast Res. 4:1–27, 1990.Google Scholar
  11. Denker, H.-W., and Aplin, J.D., eds: Trophoblast invasion and endometrial receptivity: novel aspects of the cell biology of embryo implantation. Trophoblast Res. 4, 1990.Google Scholar
  12. Finn, C.A.: The implantation reaction. In, Biology of the Uterus. R.M. Wynn, ed., pp. 245–308. Plenum Press, New York, 1977.CrossRefGoogle Scholar
  13. Hafez, E.S.E., and Tsutsumi, Y.: Changes in endometrial vascularity during implantation and pregnancy in the rabbit. Am. J. Anat. 118:249–282, 1966.PubMedCrossRefGoogle Scholar
  14. Hertig, A.T.: Angiogenesis in the early human chorion and in the primary placenta of the macaque monkey. Contrib. Embryol. Carnegie Inst. 25:37–81, 1935.Google Scholar
  15. Hertig, A.T.: La nidation des oeufs humains fécondes normaux et anormaux. In, Les Fonctions de Nidation Uterine et Leurs Troubles. J. Ferin, and M. Gaudefroy, eds., pp. 169–213, Masson, Paris, 1960.Google Scholar
  16. Hertig, A.T., and Rock, J.: Two human ova of the previllous stage having an ovulation age of about eleven and twelve days respectively. Contrib. Embryol. Carnegie Inst. 29:127–156, 1941.Google Scholar
  17. Hertig, A.T., and Rock, J.: Two human ova of the previllous stage, having a developmental age of about seven and nine days respectively. Contrib. Embryol. Carnegie Inst. 31:65–84, 1945.Google Scholar
  18. Hertig, A.T., and Rock, J.: Two human ova of the previllous stage, having a developmental age of about eight and nine days respectively. Contrib. Embryol. Carnegie Inst. 33:169–186, 1949.Google Scholar
  19. Heuser, C.H., and Streeter, G.L.: Development of the macaque embryo. Contrib. Embryol. Carnegie Inst. 29:15–55, 1941.Google Scholar
  20. Hoos, P.G., and Hoffman, L.H.: Temporal aspects of rabbit uterine vascular and decidual responses to blastocyst stimulation. Biol. Reprod. 23:453–459, 1980.PubMedCrossRefGoogle Scholar
  21. Hustin, J., Schaaps, J.P., and Lambotte, R.: Anatomical studies of the uteroplacental vascularization in the first trimester of pregnancy. Trophoblast Res. 3:49–60, 1988.Google Scholar
  22. Kaiser, R.: Über die Rückbildungsvorgänge in der Decidua während der Schwangerschaft. Arch. Gynäkol. 192:209–220, 1960.PubMedCrossRefGoogle Scholar
  23. Kaufmann, P.: Placentation und Placenta. In, Human-embryologie. K.V. Hinrichsen, ed., Springer-Verlag, Heidelberg, 1990.Google Scholar
  24. Kaufmann, P., and Scheffen, I.: Placental development. In, Neonatal and Fetal Medicine—Physiology and Pathophysiology. R. Polin and W Fox, eds. Saunders, Orlando, 1990.Google Scholar
  25. King, B.F.: Ultrastructural differentiation of stromal and vascular components in early macaque placental villi. Am. J. Anat. 178:30–44, 1987.PubMedCrossRefGoogle Scholar
  26. Larsen, J.F.: Electron microscopy of the implantation site in the rabbit. Am. J. Anat. 109:319–334, 1961.PubMedCrossRefGoogle Scholar
  27. Larsen, J.F.: Electron microscopy of nidation in the rabbit and observations on the human trophoblastic invasion. In, Ovo-Implantation, Human Gonadotrophins and Prolactin. P.O. Hubinont, F. Leroy, C. Robyn, and P. Leleux, eds., pp. 38–51. S. Karger, Basel, 1970.Google Scholar
  28. Leiser, R., and Beier, H.M.: Morphological studies of lacunar formation in the early rabbit placenta. Trophoblast Res. 3:97–110, 1988.Google Scholar
  29. Luckett, W.P.: Origin and differentiation of the yolk sac and extraembryonic mesoderm in presomite human and rhesus monkey embryos. Am. J. Anat. 152:59–97, 1978.PubMedCrossRefGoogle Scholar
  30. Mossman, H.W.: Comparative morphogenesis of the fetal membranes and accessory uterine structures. Carnegie Contrib. Embryol. 26:129–246, 1937.Google Scholar
  31. Mossman, H.W.: Vertebrate Fetal Membranes: Comparative Ontogeny and Morphology; Evolution; Phylogenetic Significance; Basic Functions; Research Opportunities. Macmillan, London, 1987.Google Scholar
  32. Park, W.W.: Choriocarcinoma: A Study of Its Pathology, pp. 13–27. Heinemann, London, 1971.Google Scholar
  33. Pijnenborg, R., Robertson, W.B., Brosens, I., and Dixon, G.: Trophoblast invasion and the establishment of haemochorial placentation in man and laboratory animals. Placenta 2:71–92, 1981.PubMedCrossRefGoogle Scholar
  34. Psychoyos, A.: The “implantation window”: can it be enlarged or displaced? In Human Reproduction. Excerpta Med. Int. Congr. Ser. 768:231–232, 1988.Google Scholar
  35. Robertson, W.B., and Warner, B.: The ultrastructure of the human placental bed. J. Pathol. 112:203–211, 1974.PubMedCrossRefGoogle Scholar
  36. Schaaps, J.P., and Hustin, J.: In vivo aspect of the maternal-trophoblastic border during the first trimester of gestation. Trophoblast Res. 3:3–48, 1988.Google Scholar
  37. Schlafke, S., and Enders, A.C.: Cellular basis of interaction between trophoblast and uterus in implantation. Biol. Reprod. 12:41–65, 1975.PubMedCrossRefGoogle Scholar
  38. Steven, D.H.: Interspecies differences in the structure and function of trophoblast. In, Biology of Trophoblast. Y.W. Loke, and A. Whyte, eds., pp. 111–136. Elsevier, Amsterdam, 1983.Google Scholar
  39. Tedde, G., Tedde Piras, A., and Berta, R.: A new structural pattern of the human trophoblast: the syncytial units. In, Abstracts of the 11th Rochester Trophoblast Conference, no. 117, 1988a.Google Scholar
  40. Tedde, G., Tedde Piras, A., and Fenu, G.: Demonstration of an intercellular pathway of transport in the human trophoblast. In, Abstracts of the 11th Rochester Trophoblast Conference, no. 77, 1988b.Google Scholar
  41. Welsh, A.O., and Enders, A.E.: Light and electron microscopic examination of the mature decidual cells of the rat with emphasis on the antimesometrial decidua and its degeneration. Am. J. Anat. 172:1–29, 1985.PubMedCrossRefGoogle Scholar
  42. Wislocki, G.B., and Streeter, G.L.: On the placentation of the macaque (Macaca mulatta) from the time of implantation until the formation of the definitive placenta. Contrib. Embryol. Carnegie Inst. 27:1–66, 1938.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Kurt Benirschke
    • 1
    • 2
  • Peter Kaufmann
    • 3
  1. 1.Pathology and Reproductive MedicineUniversity of CaliforniaSan DiegoUSA
  2. 2.University Medical CenterSan DiegoUSA
  3. 3.Institut für Anatomie der Medizinischen Fakultät, Rheinisch-Westfälische TechnischeHochschule AachenAachenGermany

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