Latices and Thermosensitive Gels as Sustained Delivery Systems to the Eye
Traditionally, ophthalmic formulations have been limited to solutions or ointments and in some rare cases to emulsions or suspensions. An alternative is the use of carefully selected pH-sensitive polymeric materials dispersed in water in the nanometer size range as carriers or polymers with interesting sol-gel transition behavior. These two systems have been formulated and further investigated in order to slow down the extremely rapid drug exchange between the tear fluid and the medicament.
KeywordsArea Under Curve Mean Residence Time Polymeric Dispersion Nanometer Size Range Ophthalmic Formulation
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