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Ophthalmic Drug Delivery pp 179–189Cite as

Controlled Drug Release from Monolithic Systems

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Part of the book series: FIDIA Research Series ((FIDIA,volume 11))

Abstract

Controlled drug release from monolithic systems can be achieved by diffusion, swelling, or erosion. In diffusion-controlled systems the drug is dissolved or dispersed in a polymer matrix and allowed to diffuse from the monolith. In swelling-controlled systems the drug is immobilized in a glassy, hydrophilic polymer and is released as a swelling front moves into the matrix. In chemically controlled systems, rate of drug release is controlled by a combination of diffusion and erosion or in special cases, by erosion alone.

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Author information

Authors and Affiliations

  1. Polymer Sciences Department, SRI International, Menlo Park, CA, 94025, USA

    J. Heller

Authors
  1. J. Heller
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Editor information

Editors and Affiliations

  1. Istituto di Chimica Farmaceutica, dell’Università di Pisa, Pisa, Italy

    Marco Fabrizio Saettone

  2. Clinica Oculistica, Università dell’Aquila, Pisa, Italy

    Massimo Bucci

  3. Pharmazeutisches Institut ETHZ, Zurich, Switzerland

    P. Speiser

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© 1987 Springer Science+Business Media New York

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Heller, J. (1987). Controlled Drug Release from Monolithic Systems. In: Saettone, M.F., Bucci, M., Speiser, P. (eds) Ophthalmic Drug Delivery. FIDIA Research Series, vol 11. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4175-9_18

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  • DOI: https://doi.org/10.1007/978-1-4757-4175-9_18

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-4177-3

  • Online ISBN: 978-1-4757-4175-9

  • eBook Packages: Springer Book Archive

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